Nucynta and Dexamethasone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Dexamethasone (dexamethasone). Common drug interactions include gait disturbance among females and rash maculo-papular among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Dexamethasone. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Dexamethasone?

Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 161,927 Dexamethasone users. Check the latest studies of Dexamethasone.

On Jul, 16, 2026

48 people who take Nucynta and Dexamethasone together, and have interactions are studied.

Nucynta and Dexamethasone drug interactions.

What are the common drug interactions of Nucynta and Dexamethasone, by gender? *:

female:

Gait disturbance
Hallucination (an experience involving the perception of something not present)
Heart rate increased
Hospitalisation
Hypoacusis (loss of hearing)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Insomnia (sleeplessness)
Joint stiffness
Joint swelling
Knee deformity (functional disability of knee)

male:

Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Heart rate increased
Insomnia (sleeplessness)
Loss of consciousness
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Neck pain
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Dyspnoea (difficult or laboured respiration)
Muscle spasms (muscle contraction)

What are the common drug interactions of Nucynta and Dexamethasone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Arthralgia (joint pain)
Behcet's syndrome (involves inflammation of the blood vessels)
Constipation
Depression
Diarrhoea
Eye pain
Fatigue (feeling of tiredness)
Headache (pain in head)

50-59:

Pleural effusion (water on the lungs)
Abdominal distension
Abdominal pain
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
C-reactive protein increased
Clubbing (deformity of the fingers and fingernails)
Dehydration (dryness resulting from the removal of water)
Diarrhoea

60+:

Fatigue (feeling of tiredness)
Spinal fracture (fracture in one of vertebrae)
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)
Disease progression
Renal cancer (cancer of kidney)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood potassium decreased

What are the existing conditions these people have? *

Constipation: 9 people, 18.75%
Nausea (feeling of having an urge to vomit): 8 people, 16.67%
Back Pain: 7 people, 14.58%
Cough: 7 people, 14.58%
Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 6 people, 12.50%
Erythema Multiforme (a type of hypersensitivity reaction): 6 people, 12.50%
Coughing Up Blood: 6 people, 12.50%
Dermatitis Acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis): 6 people, 12.50%
Abdominal Pain Upper: 6 people, 12.50%
Productive Cough: 6 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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