Nucynta and Xopenex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Xopenex (levalbuterol hydrochloride). Common drug interactions include dyspnoea among females and ankle fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Xopenex. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Xopenex?

Xopenex has active ingredients of levalbuterol hydrochloride. It is often used in asthma. eHealthMe is studying from 13,816 Xopenex users. Check the latest studies of Xopenex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

31 people who take Nucynta and Xopenex together, and have interactions are studied.

What are the common drug interactions of Nucynta and Xopenex, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Chronic kidney disease
Renal failure (kidney dysfunction)
Pneumonia
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Cardiac arrest
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Sepsis (a severe blood infection that can lead to organ failure and death)
Throat tightness

male:

Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Prostate cancer
Vitamin d deficiency
Bone disorder
Cervical vertebral fracture
Craniocerebral injury (injury to cranium and brain)
Depression
Multiple fractures
Neoplasm malignant (cancer tumour)

What are the common drug interactions of Nucynta and Xopenex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Arrhythmia (irregular heartbeat)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Cardiac arrest
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Sepsis (a severe blood infection that can lead to organ failure and death)
Renal injury (kidney injury)
Cardiac failure congestive
Drug ineffective
Hepatic failure (liver failure)

60+:

Dyspnoea (difficult or laboured respiration)
Anaphylactic reaction (serious allergic reaction)
Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bone disorder
Cervical vertebral fracture
Chronic kidney disease
Craniocerebral injury (injury to cranium and brain)
Death
Depression

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 29.03%
Stress And Anxiety: 8 people, 25.81%
High Blood Cholesterol: 7 people, 22.58%
Hypersensitivity: 7 people, 22.58%
Depression: 7 people, 22.58%
Infection: 6 people, 19.35%
High Blood Pressure: 5 people, 16.13%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 16.13%
Insomnia (sleeplessness): 5 people, 16.13%
Constipation: 5 people, 16.13%

* Approximation only. Some reports may have incomplete information.

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