Nuedexta and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nuedexta (dextromethorphan hydrobromide; quinidine sulfate) and Provigil (modafinil). Common drug interactions include ill-defined disorder among females and asthma among males.

The phase IV clinical study analyzes what interactions people have when they take Nuedexta and Provigil. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Nuedexta?

Nuedexta has active ingredients of dextromethorphan hydrobromide; quinidine sulfate. eHealthMe is studying from 3,781 Nuedexta users. Check the latest studies of Nuedexta.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Jul, 09, 2026

73 people who take Nuedexta and Provigil together, and have interactions are studied.

Nuedexta and Provigil drug interactions.

What are the common drug interactions of Nuedexta and Provigil, by gender? *:

female:

Ill-defined disorder
Joint lock
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tremor (trembling or shaking movements in one or more parts of your body)
Visual impairment
Hypervigilance
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Somatisation disorder (a long-term (chronic) condition in which a person has physical symptoms that involve more than one part of the body)
Contusion (a type of hematoma of tissue in which capillaries)
Crying

male:

Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Leukopenia (less number of white blood cells in blood)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Serum serotonin decreased
Urinary tract infection
Acute myocardial infarction (acute heart attack)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cardiac arrest

What are the common drug interactions of Nuedexta and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Leukopenia (less number of white blood cells in blood)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Blood testosterone decreased
Feeling hot
Gastrointestinal motility disorder (abnormal intestinal contractions)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Serum serotonin decreased

40-49:

Drug hypersensitivity
Eye pain
Eye swelling
Flushing (the warm, red condition of human skin)
Lacrimation increased
Lagophthalmos (the inability to close the eyelids completely)
Liver disorder (liver diseases)
Lymphadenopathy (disease or enlargement of lymph nodes)
Migraine (headache)
Muscle fatigue (a condition in which muscles cannot exert their normal force)

50-59:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Blood glucose fluctuation
Depression
Nocturia (the need to get up in the night to urinate)
Obesity (having too much body fat)
Osteoporosis (bones weak and more likely to break)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tardive dyskinesia (a disorder that involves involuntary movements)
Muscle spasms (muscle contraction)

60+:

Urinary tract infection
Anal haemorrhage
Dry mouth
Pyrexia (fever)
Urinary tract pain
Urine flow decreased
Vision blurred
Arthralgia (joint pain)
Cerebral haematoma (collection of blood in brain)
Cerebral haemorrhage (bleeding within the brain)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 39 people, 53.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 19.18%
Gait Disturbance: 9 people, 12.33%
Affect Lability (emotional incontinence): 8 people, 10.96%
Muscle Spasms (muscle contraction): 4 people, 5.48%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 5.48%
Fatigue (feeling of tiredness): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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