Omeprazole and Silenor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Omeprazole (omeprazole) and Silenor (doxepin hydrochloride). Common drug interactions include constipation among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Omeprazole and Silenor. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,631 Omeprazole users. Check the latest studies of Omeprazole.

What is Silenor?

Silenor has active ingredients of doxepin hydrochloride. It is often used in insomnia. eHealthMe is studying from 635 Silenor users. Check the latest studies of Silenor.

On Jul, 12, 2026

68 people who take Omeprazole and Silenor together, and have interactions are studied.

Omeprazole and Silenor drug interactions.

What are the common drug interactions of Omeprazole and Silenor, by gender? *:

female:

Constipation
Hyperhidrosis (abnormally increased sweating)
Chronic kidney disease
Drug dependence
Pneumonia
Alopecia (absence of hair from areas of the body)
Fatigue (feeling of tiredness)
Renal injury (kidney injury)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)

male:

Vomiting
Coccydynia (pain in the coccyx or tailbone area)
Blood pressure diastolic increased
Constipation
Drug effect decreased
Gastrointestinal tract adenoma (a benign tumour (-oma) of glandular origin in digestive tract)
Headache (pain in head)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Nasopharyngitis (inflammation of the nasopharynx)
Peripheral swelling

What are the common drug interactions of Omeprazole and Silenor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dizziness postural
Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Presyncope
Decreased appetite
Weight decreased
Alopecia (absence of hair from areas of the body)
Nausea (feeling of having an urge to vomit)

30-39:

n/a

40-49:

Headache (pain in head)
Abdominal distension
Anxiety
Arthralgia (joint pain)
Blood pressure diastolic increased
Constipation
Drug dependence
Hip arthroplasty
Hyperhidrosis (abnormally increased sweating)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)

50-59:

Alopecia (absence of hair from areas of the body)
Coccydynia (pain in the coccyx or tailbone area)
Colitis ulcerative (inflammation of colon with ulcer)
Drug level decreased
Fatigue (feeling of tiredness)
Hair colour changes
Hair disorder
Nausea (feeling of having an urge to vomit)
Peritonsillar abscess (painful pus filled inflammation of the tonsils and surrounding tissues)
Vomiting

60+:

Chronic kidney disease
Renal injury (kidney injury)
Emotional distress
Fatigue (feeling of tiredness)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Nephropathy (damage to or disease of a kidney)
Ovarian cancer (cancer of ovary)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 25.00%
Pain: 16 people, 23.53%
Sleep Disorder: 14 people, 20.59%
Nausea (feeling of having an urge to vomit): 13 people, 19.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 19.12%
Stress And Anxiety: 11 people, 16.18%
High Blood Pressure: 9 people, 13.24%
Drowsiness: 9 people, 13.24%
Diarrhea: 8 people, 11.76%
Birth Control: 8 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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