Omnicef and Lomotil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Omnicef (cefdinir) and Lomotil (atropine sulfate; diphenoxylate hydrochloride). Common drug interactions include decreased appetite among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Omnicef and Lomotil. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Omnicef?

Omnicef has active ingredients of cefdinir. It is often used in sinusitis. eHealthMe is studying from 2,774 Omnicef users. Check the latest studies of Omnicef.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

On Jul, 16, 2026

26 people who take Omnicef and Lomotil together, and have interactions are studied.

What are the common drug interactions of Omnicef and Lomotil, by gender? *:

female:

Decreased appetite
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea haemorrhagic (bloody diarrhoea)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dry eye (lack of adequate tears)
Dry mouth
Dysarthria (speech disorder)
Dyspnoea at rest (difficult or laboured breathing during rest)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Dysuria (painful or difficult urination)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Metastases to liver (cancer spreads to liver)
Abortion spontaneous (naturally occurring miscarriage)
Acute respiratory failure
Cerebral haematoma (collection of blood in brain)
Chronic kidney disease
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injection site pain

What are the common drug interactions of Omnicef and Lomotil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depression
Pyrexia (fever)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pain in extremity
Cholecystitis (infection of gallbladder)
Local swelling (swelling at the site of some application of substance or injury)

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
Inflammatory bowel disease
Intestinal obstruction
Liver abscess (pus in liver)
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Injury
Pain
Pain in extremity
Peripheral swelling
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

40-49:

Metastases to liver (cancer spreads to liver)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Injection site haemorrhage (bleeding from injection site)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

50-59:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea haemorrhagic (bloody diarrhoea)
Dyspnoea at rest (difficult or laboured breathing during rest)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Hepatic steatosis (fatty liver disease)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Klebsiella bacteraemia (klebsiella bacteria in blood after infection to lungs)

60+:

Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Abasia (inability to walk)
Abdominal discomfort
Abdominal pain
Abdominal pain upper
Adenomatous polyposis coli ((fap) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine)
Alanine aminotransferase increased
Anaemia (lack of blood)
Antiphospholipid antibodies positive

What are the existing conditions these people have? *

Pain: 6 people, 23.08%
Rectal Cancer (cancer of rectum): 5 people, 19.23%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 15.38%
Stress And Anxiety: 3 people, 11.54%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.54%
Premenstrual Syndrome: 2 people, 7.69%
Nausea (feeling of having an urge to vomit): 2 people, 7.69%
Menstruation Irregular: 2 people, 7.69%
Dysmenorrhea (painful menstruation): 2 people, 7.69%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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