Opzelura and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opzelura (ruxolitinib phosphate) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include headache among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Opzelura and Hydroxyzine. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Opzelura?

Opzelura has active ingredients of ruxolitinib phosphate. eHealthMe is studying from 1,961 Opzelura users. Check the latest studies of Opzelura.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 09, 2026

37 people who take Opzelura and Hydroxyzine together, and have interactions are studied.

Opzelura and Hydroxyzine drug interactions.

What are the common drug interactions of Opzelura and Hydroxyzine, by gender? *:

female:

Headache (pain in head)
Injection site pain
Fatigue (feeling of tiredness)
Rash
Skin exfoliation (removal of the oldest dead skin cells)
Peripheral swelling
Skin fissures (a crack in the skin)
Drug ineffective
Dry eye (lack of adequate tears)
Dry skin

male:

Drug ineffective
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Skin exfoliation (removal of the oldest dead skin cells)
Skin fissures (a crack in the skin)
Scratch
Skin swelling
Chest pain
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Erythema (redness of the skin)
Myalgia (muscle pain)

What are the common drug interactions of Opzelura and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dry skin
Skin exfoliation (removal of the oldest dead skin cells)
Weight increased

30-39:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Cataract (clouding of the lens inside the eye)
Drug ineffective
Dry eye (lack of adequate tears)
Dry skin
Skin fissures (a crack in the skin)
Skin haemorrhage (bleeding into skin)
Sleep disorder

40-49:

Headache (pain in head)
Injection site pain
Arthralgia (joint pain)
Bone swelling
Fatigue (feeling of tiredness)
Injection site swelling
Peripheral swelling
Therapeutic response decreased (less preventive response)
Conjunctivitis (pink eye)
Drug ineffective

50-59:

Fatigue (feeling of tiredness)
Headache (pain in head)
Weight increased
Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthma
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Back pain
Balance disorder
Chest pain

60+:

Dental caries
Drug ineffective
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eye disorder
Hernia obstructive (obstruction in the bowel; interrupt the blood supply to the herniated tissue)
Psoriasis (immune-mediated disease that affects the skin)
Tooth abscess (pus formation in tooth)

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 29 people, 78.38%
Asthma: 3 people, 8.11%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 5.41%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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