Ortho-est and Prempro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ortho-est (estropipate) and Prempro (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include breast cancer among females and breast cancer female among males.

The phase IV clinical study analyzes what interactions people have when they take Ortho-est and Prempro. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Ortho-est?

Ortho-est has active ingredients of estropipate. eHealthMe is studying from 52 Ortho-est users. Check the latest studies of Ortho-est.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

On Aug, 09, 2026

19 people who take Ortho-est and Prempro together, and have interactions are studied.

Ortho-est and Prempro drug interactions.

What are the common drug interactions of Ortho-Est and Prempro, by gender? *:

female:

Breast cancer
Breast cancer female
Menstruation delayed (late menstruation cycle)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Thrombosis (formation of a blood clot inside a blood vessel)

male:

Breast cancer female
Ovarian cancer (cancer of ovary)
Breast cancer
Chondropathy (disease of the cartilage)
Deformity (disfigurement)
Depression
Dyspepsia (indigestion)
Haematemesis (vomiting of blood)
Injury
Lung disorder (lung disease)

What are the common drug interactions of Ortho-Est and Prempro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Breast cancer female
Menstruation delayed (late menstruation cycle)

40-49:

Breast cancer female
Abdominal hernia
Chest pain
Hyperhidrosis (abnormally increased sweating)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)

50-59:

Chondropathy (disease of the cartilage)
Deformity (disfigurement)
Depression
Dyspepsia (indigestion)
Haematemesis (vomiting of blood)
Injury
Lung disorder (lung disease)
Neuralgia (pain in one or more nerves)
Neuropathy peripheral (surface nerve damage)
Oestrogen receptor assay positive

60+:

Breast cancer female
Ovarian cancer (cancer of ovary)
Haemorrhage (bleeding)
Breast cancer

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.26%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 5.26%
Erection Problems: 1 person, 5.26%
Depression: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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