Oyster shell calcium and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oyster shell calcium (calcium carbonate) and Methotrexate (methotrexate sodium). Common drug interactions include menorrhagia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Oyster shell calcium and Methotrexate. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Oyster shell calcium?

Oyster shell calcium has active ingredients of calcium carbonate. eHealthMe is studying from 416 Oyster shell calcium users. Check the latest studies of Oyster shell calcium.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 09, 2026

11 people who take Oyster shell calcium and Methotrexate together, and have interactions are studied.

Oyster shell calcium and Methotrexate drug interactions.

What are the common drug interactions of Oyster Shell Calcium and Methotrexate, by gender? *:

female:

Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Arthralgia (joint pain)
Drug ineffective
Pain in extremity
Uterine haemorrhage (uterine bleeding)
Back pain
Blood glucose increased
Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cough

male:

Anaemia (lack of blood)
Anal abscess
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Erythema (redness of the skin)
Gait disturbance
Headache (pain in head)
Hypersensitivity
Ill-defined disorder
Joint swelling

What are the common drug interactions of Oyster Shell Calcium and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Back pain
Cellulitis (infection under the skin)
Drug ineffective
Feeling cold
Gastric bypass
Gastrointestinal stromal tumour (a cancer that arises from transformed cells of mesenchymal origin in gastrointestinal tract)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hot flush (sudden feelings of heat)
Hypoglycaemia (deficiency of glucose in the bloodstream)

40-49:

Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Uterine haemorrhage (uterine bleeding)
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)

50-59:

n/a

60+:

Pain in extremity
Arthralgia (joint pain)
Pain
Viral infection
Weight increased
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cough
Headache (pain in head)
Memory impairment

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 2 people, 18.18%
Type 2 Diabetes: 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Asthma: 1 person, 9.09%
Bone Disorder: 1 person, 9.09%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 9.09%
Diabetes: 1 person, 9.09%
Diarrhea: 1 person, 9.09%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 9.09%
Gastric Disorder (disease of stomach): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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