Pacerone and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pacerone (amiodarone hydrochloride) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include sudden death among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Pacerone and Benadryl. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Pacerone?

Pacerone has active ingredients of amiodarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 2,814 Pacerone users. Check the latest studies of Pacerone.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 11, 2026

41 people who take Pacerone and Benadryl together, and have interactions are studied.

Pacerone and Benadryl drug interactions.

What are the common drug interactions of Pacerone and Benadryl, by gender? *:

female:

Sudden death
Feeling hot
Pain
Pain in extremity
Temperature intolerance (inability to go in temperature)
Adverse drug reaction
Asthenia (weakness)
Carotid artery stenosis (narrowing of carotid artery)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort

male:

Renal failure (kidney dysfunction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Pulmonary embolism (blockage of the main artery of the lung)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Fungaemia (fungi circulate in the blood)
Renal disorder (kidney disease)
Renal mass (mass in kidney)
Abdominal pain lower

What are the common drug interactions of Pacerone and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac fibrillation (uncontrolled muscle contraction of heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased

50-59:

Urinary tract infection
Wound infection
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal disorder (kidney disease)
Renal mass (mass in kidney)
Acute respiratory distress syndrome
Blood pressure diastolic decreased
Carotid artery stenosis (narrowing of carotid artery)

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Atrial thrombosis (blood clot that develops in an artery)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriosclerosis (thickening and hardening of arteries)
Asthenia (weakness)
Cardiac procedure complication
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral atrophy (decrement in size of brain)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 17.07%
Pain: 4 people, 9.76%
Nausea (feeling of having an urge to vomit): 4 people, 9.76%
Multiple Allergies (allergy to multiple agents): 4 people, 9.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.76%
High Blood Pressure: 4 people, 9.76%
Cardiac Disorder: 4 people, 9.76%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 7.32%
Multiple Myeloma (cancer of the plasma cells): 3 people, 7.32%
Itching: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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