Pantoprazole and Synephrine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pantoprazole (pantoprazole sodium) and Synephrine (bitter orange). Common drug interactions include anxiety among females and necrotising enterocolitis neonatal among males.

The phase IV clinical study analyzes what interactions people have when they take Pantoprazole and Synephrine. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 285,170 Pantoprazole users. Check the latest studies of Pantoprazole.

What is Synephrine?

Synephrine has active ingredients of bitter orange. It is often used in weight loss. eHealthMe is studying from 257 Synephrine users. Check the latest studies of Synephrine.

eHealthMe: drug outcomes in the real world

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On Sep, 02, 2026

15 people who take Pantoprazole and Synephrine together, and have interactions are studied.

Pantoprazole and Synephrine drug interactions.

What are the common drug interactions of Pantoprazole and Synephrine, by gender? *:

female:

Anxiety
Depression
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
Fear
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Injury
Multi-organ failure (multisystem organ failure)

male:

Necrotising enterocolitis neonatal (life threatening infection of intestine in newborn baby)
Acute respiratory failure
Haemoglobin decreased
Hypotonia (low muscle tone)
Mydriasis (a dilation of the pupil)
Platelet count decreased
Staphylococcus test positive
Blood glucose fluctuation
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Pantoprazole and Synephrine, by age (0-1 to 60+)? *:

0-1:

Necrotising enterocolitis neonatal (life threatening infection of intestine in newborn baby)
Apnoea (suspension of external breathing)
Atelectasis (partial or complete collapse of the lung)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Haemoglobin decreased
Hypotonia (low muscle tone)
Mydriasis (a dilation of the pupil)
Platelet count decreased
Staphylococcus test positive

2-9:

n/a

10-19:

n/a

20-29:

Respiratory disorder (respiratory disease)
Pulmonary vascular disorder

30-39:

n/a

40-49:

n/a

50-59:

Anxiety
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Emotional distress
Fear
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Injury
Multi-organ failure (multisystem organ failure)

60+:

Acute respiratory failure
Anaemia (lack of blood)
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Chills (felling of cold)
Death
Decreased appetite
Depression
Diarrhoea

What are the existing conditions these people have? *

Anaemia (lack of blood): 2 people, 13.33%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 2 people, 13.33%
Bronchopulmonary Dysplasia (chronic lung disorder in infants - enlargement of an organ or tissue by the proliferation of cells of an abnormal type): 2 people, 13.33%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 1 person, 6.67%
Asthma: 1 person, 6.67%
Depression: 1 person, 6.67%
Diabetes: 1 person, 6.67%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 1 person, 6.67%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 1 person, 6.67%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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