Paracetamol and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paracetamol (acetaminophen) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include drug ineffective among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Paracetamol and Hydrocodone. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 20, 2026

24 people who take Paracetamol and Hydrocodone together, and have interactions are studied.

Paracetamol and Hydrocodone drug interactions.

What are the common drug interactions of Paracetamol and Hydrocodone, by gender? *:

female:

Drug ineffective
Drug dependence
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Learning disability (difficulty in learning)
Abdominal discomfort
Accident
Adverse event
Adverse reaction
Alopecia (absence of hair from areas of the body)

male:

Fall
Abscess soft tissue (soft tissue abscesses)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Tibia fracture (fracture of lower leg bone)
Drug dependence
Hypersensitivity
Purpura (purplish discoloration of the skin)
Aggression
Anxiety
Bipolar disorder (mood disorder)

What are the common drug interactions of Paracetamol and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Accident
Overdose

30-39:

Drug abuse

40-49:

Alopecia (absence of hair from areas of the body)

50-59:

n/a

60+:

Drug ineffective
Adverse event
Adverse reaction
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Haemoglobin decreased
Hypotension (abnormally low blood pressure)
Somnolence (a state of near-sleep, a strong desire for sleep)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 12.50%
Burning Mouth Syndrome (pain in the mouth and burning sensation on tongue): 3 people, 12.50%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.33%
Herpes Zoster: 2 people, 8.33%
Depression: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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