Paxil and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxil (paroxetine hydrochloride) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include renal failure among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Paxil and Isosorbide dinitrate. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 16, 2026

92 people who take Paxil and Isosorbide dinitrate together, and have interactions are studied.

Paxil and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Paxil and Isosorbide Dinitrate, by gender? *:

female:

Renal failure (kidney dysfunction)
Weight increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dyspnoea exertional (breathlessness or shortness of breath)
Ill-defined disorder
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Urinary tract infection

male:

Cardiac failure congestive
Somnolence (a state of near-sleep, a strong desire for sleep)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Fatigue (feeling of tiredness)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Multiple injuries
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)

What are the common drug interactions of Paxil and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

30-39:

Dizziness
Flushing (the warm, red condition of human skin)
Skin warm

40-49:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Asthenia (weakness)
Athetosis (a condition in which abnormal muscle contractions cause involuntary writhing movements)
Atrioventricular block (heart block)
Bradycardia (abnormally slow heart action)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Choreoathetosis (involuntary movement randomly from one part to another body part)
Colonic polyp (extra part of colon tissue grow in intestine)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery restenosis (recurrence of narrowing of artery)

50-59:

Diarrhoea
Adhesion
Anaemia (lack of blood)
Atrioventricular block first degree (heart block first degree)
Carotid artery stenosis (narrowing of carotid artery)
Cataract (clouding of the lens inside the eye)
Cerebral haemorrhage (bleeding within the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cutaneous sarcoidosis (a multisystem disease with skin lesion)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

Dyspnoea (difficult or laboured respiration)
Fall
Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Multiple injuries
Nausea (feeling of having an urge to vomit)
Pain
Activities of daily living impaired
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 19.57%
Diabetes: 9 people, 9.78%
Pain: 8 people, 8.70%
High Blood Cholesterol: 7 people, 7.61%
Cardiac Disorder: 7 people, 7.61%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 7.61%
Stable Angina (a constant chest pain): 6 people, 6.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 6.52%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 6.52%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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