Pentasa and Azulfidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pentasa (mesalamine) and Azulfidine (sulfasalazine). Common drug interactions include hepatitis among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Pentasa and Azulfidine. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

What is Azulfidine?

Azulfidine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. eHealthMe is studying from 7,997 Azulfidine users. Check the latest studies of Azulfidine.

On Jul, 18, 2026

37 people who take Pentasa and Azulfidine together, and have interactions are studied.

Pentasa and Azulfidine drug interactions.

What are the common drug interactions of Pentasa and Azulfidine, by gender? *:

female:

Hepatitis (inflammation of the liver)
Herpes zoster
Hydronephrosis (water inside the kidney)
Hyperpyrexia (extremely high fever)
Hypertension (high blood pressure)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Immunosuppression
Implant infection (infection at implant site)
Injection site pain
Injection site rash

male:

Asthenia (weakness)
Balance disorder
Blood glucose fluctuation
Cardiac failure
Erythema multiforme (a type of hypersensitivity reaction)
Face oedema (swelling of face)
Herpes simplex (herpes simplex is a common viral infection)
Myocarditis (inflammation of heart muscle myocardium)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)

What are the common drug interactions of Pentasa and Azulfidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Haematuria (presence of blood in urine)
Nephritis (inflammation of the nephrons in the kidneys)
Proteinuria (presence of protein in the urine)

10-19:

n/a

20-29:

Platelet count decreased

30-39:

Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)
Osteoporosis (bones weak and more likely to break)
Ovarian cyst (fluid filled sac of the ovary)
Rash pruritic (redness with itching)
Salpingitis (an infection and inflammation in the fallopian tubes)
Shivering
Stress symptoms
Vaginal discharge
Vaginal mycosis (vaginal fungal infection)

40-49:

Cardiac failure
Generalised oedema (swelling all over the body)
Myocarditis (inflammation of heart muscle myocardium)
Troponin i increased

50-59:

Arthralgia (joint pain)
Oedema (fluid collection in tissue)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ataxia (loss of full control of bodily movements)
Balance disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Dysarthria (speech disorder)
Gait disturbance
Muscular weakness (muscle weakness)

60+:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Gastroenteritis (inflammation of stomach and intestine)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Diarrhoea
Eye pruritus (eye itching)
Headache (pain in head)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic steatosis (fatty liver disease)
Impaired healing

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 21.62%
Pain: 7 people, 18.92%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 13.51%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 10.81%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 8.11%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 8.11%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 8.11%
Asthma: 3 people, 8.11%
Blood Glucose Fluctuation: 3 people, 8.11%
Colitis (inflammation of colon): 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

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