Pepcid ac and Diflucan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pepcid ac (famotidine) and Diflucan (fluconazole). Common drug interactions include gastroenteritis eosinophilic among females and blood potassium decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Pepcid ac and Diflucan. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Pepcid ac?

Pepcid ac has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,573 Pepcid ac users. Check the latest studies of Pepcid ac.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

58 people who take Pepcid ac and Diflucan together, and have interactions are studied.

Pepcid ac and Diflucan drug interactions.

What are the common drug interactions of Pepcid Ac and Diflucan, by gender? *:

female:

Gastroenteritis eosinophilic (white blood cell deposits in tissue of stomach or intestine with infection)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Haemoglobin decreased
Hangover
Hemiparesis (weakness on one side of the body)
Hospitalisation
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypoglobulinaemia (deficiency of globulin in the bloodstream)
Immunodeficiency
Impaired gastric emptying

male:

Blood potassium decreased
Faecaloma (hard mass of fecal matter)
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haemorrhage (bleeding)
Hypersensitivity
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Pepcid Ac and Diflucan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

30-39:

Nephrogenic anaemia (anaemia due to kidney disease)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Right ventricular failure (right half of the heart fails to work)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Diarrhoea
Abdominal pain
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety

40-49:

Chronic kidney disease
Cystitis (inflammation of the wall of the bladder)
Renal failure (kidney dysfunction)
Kidney infection
Mucosal inflammation (infection of mucous membrane)
Catheter site cellulitis (infection of cells near catheter)
Cellulitis (infection under the skin)
Fatigue (feeling of tiredness)
Implant site reaction
Muscle spasms (muscle contraction)

50-59:

Renal failure (kidney dysfunction)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Cardiac failure congestive
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Cystitis (inflammation of the wall of the bladder)
Kidney infection
Malaise (a feeling of general discomfort or uneasiness)
Psoriasis (immune-mediated disease that affects the skin)
Renal impairment (severely reduced kidney function)

60+:

Dizziness
Injection site haemorrhage (bleeding from injection site)
Neutropenia (an abnormally low number of neutrophils)
Renal failure (kidney dysfunction)
Spider naevus (small dilated blood vessels near the surface of the skin)
Spinal column stenosis (narrowing of spinal column)
Abdominal discomfort
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Bacteraemia (presence of bacteria in the blood)

What are the existing conditions these people have? *

Pain: 19 people, 32.76%
Hypersensitivity: 13 people, 22.41%
Insomnia (sleeplessness): 12 people, 20.69%
Infection: 12 people, 20.69%
High Blood Cholesterol: 10 people, 17.24%
Headache (pain in head): 9 people, 15.52%
Stress And Anxiety: 8 people, 13.79%
High Blood Pressure: 8 people, 13.79%
Diabetes: 8 people, 13.79%
Depression: 7 people, 12.07%

* Approximation only. Some reports may have incomplete information.

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