Percocet and Dayquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percocet (acetaminophen; oxycodone hydrochloride) and Dayquil (acetaminophen; dextromethorphan; pseudoephedrine). Common drug interactions include abdominal discomfort among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Percocet and Dayquil. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Dayquil?

Dayquil has active ingredients of acetaminophen; dextromethorphan; pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 1,815 Dayquil users. Check the latest studies of Dayquil.

On Jul, 15, 2026

18 people who take Percocet and Dayquil together, and have interactions are studied.

What are the common drug interactions of Percocet and Dayquil, by gender? *:

female:

Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Cough
Drug ineffective
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Haematemesis (vomiting of blood)
Ketoacidosis (high concentrations of ketone bodies in blood)
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

male:

Abdominal pain upper
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cholecystitis (infection of gallbladder)
Cholecystitis acute (rapid infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gastric ulcer (stomach ulcer)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Pulmonary embolism (blockage of the main artery of the lung)

What are the common drug interactions of Percocet and Dayquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Anxiety
Drug administration error
Emotional distress
Headache (pain in head)
Injury
Overdose
Pulmonary embolism (blockage of the main artery of the lung)
Transaminases increased
Vomiting

30-39:

Alopecia (absence of hair from areas of the body)
Depression
Hair colour changes
Hair disorder

40-49:

Abdominal discomfort
Cough
Stomatitis (inflammation of mucous membrane of mouth)
Vomiting
Abdominal pain upper
Cholecystitis (infection of gallbladder)
Cholecystitis acute (rapid infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dysphonia (speech disorder attributable to a disorder of phonation)
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 5 people, 27.78%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 16.67%
Cough: 3 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
Headache (pain in head): 2 people, 11.11%
Drowsiness: 2 people, 11.11%
Breast Cancer Female: 2 people, 11.11%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.56%
Respiratory Tract Congestion (blockage on respiratory system): 1 person, 5.56%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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