Periactin and Alprazolam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Alprazolam (alprazolam). Common drug interactions include upper respiratory tract infection among females and stevens johnson syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Alprazolam. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Alprazolam?

Alprazolam has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 134,864 Alprazolam users. Check the latest studies of Alprazolam.

On Jul, 12, 2026

17 people who take Periactin and Alprazolam together, and have interactions are studied.

Periactin and Alprazolam drug interactions.

What are the common drug interactions of Periactin and Alprazolam, by gender? *:

female:

Upper respiratory tract infection
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Weight decreased
White blood cell count increased
Chronic kidney disease
Pain
Headache (pain in head)
Nephrogenic anaemia (anaemia due to kidney disease)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure (kidney dysfunction)

male:

Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Asthenia (weakness)
Diarrhoea
Disease progression
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Hypovolaemia (a decreased volume of circulating blood in the body)
Insomnia (sleeplessness)
Metastases to liver (cancer spreads to liver)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Periactin and Alprazolam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Cheilitis (infection of lips)
Pharyngitis (inflammation of the pharynx, causing a sore throat)

40-49:

Anaemia (lack of blood)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Asthenia (weakness)
Blood electrolytes decreased
Blood urea increased
Cerebral atrophy (decrement in size of brain)
Chest pain
Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death

50-59:

Acute sinusitis
Arrhythmia (irregular heartbeat)
Chronic kidney disease
Constipation
Depression
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gastritis (inflammation of stomach)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

60+:

Abdominal pain upper
Asthma
Pyrexia (fever)
Rhinorrhoea (watery mucus discharge from the nose)
Sepsis (a severe blood infection that can lead to organ failure and death)
Type 2 diabetes mellitus
Vomiting
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dizziness

What are the existing conditions these people have? *

Depression: 3 people, 17.65%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 17.65%
Pain: 2 people, 11.76%
Hot Flush (sudden feelings of heat): 2 people, 11.76%
Hypersensitivity: 2 people, 11.76%
Eye Disorder: 2 people, 11.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.76%
Colon Cancer: 1 person, 5.88%
Diarrhea: 1 person, 5.88%
Constipation: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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