Periactin and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Spironolactone (spironolactone). Common drug interactions include pyrexia among females and small intestinal obstruction among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Spironolactone. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

16 people who take Periactin and Spironolactone together, and have interactions are studied.

Periactin and Spironolactone drug interactions.

What are the common drug interactions of Periactin and Spironolactone, by gender? *:

female:

Pyrexia (fever)
Chills (felling of cold)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Death
Depressed mood
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Respiratory gas exchange disorder (gas exchange disease of respiratory system)

male:

Small intestinal obstruction (blockage in small intestine)
Chronic kidney disease
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Spinal compression fracture (fracture due to spinal compression on bone)
Viral infection
Renal failure (kidney dysfunction)
Acute respiratory failure

What are the common drug interactions of Periactin and Spironolactone, by age (0-1 to 60+)? *:

0-1:

Acute respiratory failure
Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
Corona virus infection (infection caused by a corona virus)
Dyspnoea (difficult or laboured respiration)
Influenza
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Viral infection

2-9:

Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)

10-19:

Abdominal pain upper
Blood calcium increased
Blood potassium increased
Headache (pain in head)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Injection site swelling

20-29:

n/a

30-39:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Blood potassium decreased
Feeling hot
Menstruation irregular
Metrorrhagia (uterine bleeding at irregular intervals)
Ovarian cyst (fluid filled sac of the ovary)

40-49:

Chills (felling of cold)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Death
Depressed mood
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Pyrexia (fever)
Respiratory gas exchange disorder (gas exchange disease of respiratory system)

50-59:

Small intestinal obstruction (blockage in small intestine)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Weight increased
Death
Eye swelling
Fluid retention (an abnormal accumulation of fluid in the blood)
Lip swelling
Oedema (fluid collection in tissue)
Pruritus (severe itching of the skin)
Rash

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 25.00%
Nausea And Vomiting: 3 people, 18.75%
Pain: 3 people, 18.75%
Anaemia (lack of blood): 2 people, 12.50%
Infection: 2 people, 12.50%
High Blood Pressure: 2 people, 12.50%
Wound: 1 person, 6.25%
Hypoglobulinaemia (deficiency of globulin in the bloodstream): 1 person, 6.25%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 1 person, 6.25%
Hypersensitivity: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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