Phenazopyridine hcl and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenazopyridine hcl (phenazopyridine hydrochloride) and Flonase (fluticasone propionate). Common drug interactions include generalised anxiety disorder among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Phenazopyridine hcl and Flonase. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Phenazopyridine hcl?

Phenazopyridine hcl has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,588 Phenazopyridine hcl users. Check the latest studies of Phenazopyridine hcl.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

35 people who take Phenazopyridine hcl and Flonase together, and have interactions are studied.

Phenazopyridine hcl and Flonase drug interactions.

What are the common drug interactions of Phenazopyridine Hcl and Flonase, by gender? *:

female:

Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Hypertension (high blood pressure)
Inflammatory bowel disease
Malignant melanoma (skin cancer rises from melancytes)
Uveitis (inflammation of the uvea)
Pulmonary embolism (blockage of the main artery of the lung)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Upper respiratory tract infection
Asthma
Dehydration (dryness resulting from the removal of water)

male:

Decreased appetite
Asthenia (weakness)
Abdominal distension
Abdominal pain
Anaemia (lack of blood)
Anuria (failure of the kidneys to produce urine)
Atrioventricular block first degree (heart block first degree)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Balanitis (inflammation of the glands penis)
Bladder diverticulum (pouch like projection in the bladder, by birth or acquired)

What are the common drug interactions of Phenazopyridine Hcl and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Faeces discoloured
Hypokalaemia (low potassium)

30-39:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Inflammatory bowel disease
Malignant melanoma (skin cancer rises from melancytes)
Pyelonephritis (inflammation of kidney caused by bacteria)
Renal failure acute (rapid kidney dysfunction)
Uveitis (inflammation of the uvea)
Headache (pain in head)
Muscular weakness (muscle weakness)

40-49:

Dizziness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abdominal pain
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Myalgia (muscle pain)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Diarrhoea
Haemolytic anaemia (anaemia due to haemolysis)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

60+:

Hypertension (high blood pressure)
Chest pain
Dyskinesia (abnormality or impairment of voluntary movement)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Headache (pain in head)
Mitral valve incompetence (inefficient heart valve)
Multiple injuries
Nausea (feeling of having an urge to vomit)
Pneumonia
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the existing conditions these people have? *

Depression: 8 people, 22.86%
Acne (skin problems that cause pimples): 7 people, 20.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 7 people, 20.00%
Pain: 5 people, 14.29%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.29%
Upper Respiratory Tract Infection: 5 people, 14.29%
Kidney Infection (Pyelonephritis): 5 people, 14.29%
Stress And Anxiety: 5 people, 14.29%
Birth Control: 4 people, 11.43%

* Approximation only. Some reports may have incomplete information.

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