Phenergan and Buspirone hcl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Buspirone hcl (buspirone hydrochloride). Common drug interactions include haematocrit decreased among females and drug exposure during pregnancy among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Buspirone hcl. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Buspirone hcl?

Buspirone hcl has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,821 Buspirone hcl users. Check the latest studies of Buspirone hcl.

On Jul, 07, 2026

74 people who take Phenergan and Buspirone hcl together, and have interactions are studied.

Phenergan and Buspirone hcl drug interactions.

What are the common drug interactions of Phenergan and Buspirone Hcl, by gender? *:

female:

Haematocrit decreased
Haemoglobin decreased
Hospitalisation
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Influenza like illness
Infusion site infection
Infusion site pain
Infusion site swelling
Headache (pain in head)
Abdominal pain

male:

Drug exposure during pregnancy
Mitral valve stenosis (narrowing of mitral valve)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood pressure decreased
Emergency care
Erectile dysfunction
Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)

What are the common drug interactions of Phenergan and Buspirone Hcl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Emergency care
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Suicidal ideation
Therapeutic response unexpected

20-29:

Abdominal pain
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Diarrhoea
Retching (strong involuntary effort to vomit)
Migraine (headache)
Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
Pyrexia (fever)
Sleep terror (felling of terror in sleep)
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Back pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Dyspepsia (indigestion)
Emotional distress
Fear
Hospitalisation

40-49:

Asthma
Cardiac disorder
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Headache (pain in head)
Hypersensitivity
Infusion related reaction
Lower limb fracture
Lower respiratory tract infection
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

50-59:

Constipation
Decreased appetite
Diarrhoea
Fall
Gastrointestinal infection (infection of stomach and intestine)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypertension (high blood pressure)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site rash
Initial insomnia (feeling of inadequate or poor-quality sleep)

60+:

Fall
Headache (pain in head)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Osteopenia (a condition where bone mineral density is lower than normal)
Pneumonia
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Syncope (loss of consciousness with an inability to maintain postural tone)
Ventricular extrasystoles (premature cardiac contraction)
Vulvovaginal candidiasis (vulvovaginal infection by fungi)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Depression: 15 people, 20.27%
Pain: 13 people, 17.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 13.51%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 12.16%
Asthma: 7 people, 9.46%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 9.46%
Nausea And Vomiting: 6 people, 8.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.11%
Dissociative Disorder: 5 people, 6.76%
Intervertebral Disc Degeneration (spinal disc degeneration): 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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