Phenytoin and Cipro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytoin (phenytoin) and Cipro (ciprofloxacin hydrochloride). Common drug interactions include organ failure among females and activities of daily living impaired among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytoin and Cipro. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

What is Cipro?

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 35,126 Cipro users. Check the latest studies of Cipro.

On Jul, 13, 2026

36 people who take Phenytoin and Cipro together, and have interactions are studied.

What are the common drug interactions of Phenytoin and Cipro, by gender? *:

female:

Organ failure
Vomiting
Blood potassium increased
Cholecystitis acute (rapid infection of gallbladder)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Drug ineffective
Leukocytosis (increased white blood cells)
Pancreatitis (inflammation of pancreas)
Sepsis (a severe blood infection that can lead to organ failure and death)

male:

Activities of daily living impaired
Alpha haemolytic streptococcal infection (infections with alpha-haemolytic strep bacteria are common; many strains live naturally in humans)
Osteomyelitis acute (rapid infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Pancreatic carcinoma (pancreatic cancer)
Prostatomegaly (enlargement of the prostate)
Renal cell carcinoma (a kidney cancer)
Renal mass (mass in kidney)
Small intestine carcinoma (cancer tumour of small intestine)

What are the common drug interactions of Phenytoin and Cipro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Amaurosis (partial or total blindness without visible change in the eye)
Aphasia (damage to the parts of the brain that control language)
Ataxia (loss of full control of bodily movements)
Coma (state of unconsciousness lasting more than six hours)
Depressed level of consciousness
Echolalia (meaningless repetition of another person's spoken words -psychiatric disorder)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypertension (high blood pressure)

10-19:

Optic papillitis (inflammation of the optic nerve head)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

20-29:

Cough
Haematemesis (vomiting of blood)
Hypotension (abnormally low blood pressure)
Respiratory depression (respiration has a rate below 12 breaths)

30-39:

Abdominal pain
Asthenia (weakness)
Blood pressure decreased
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)

40-49:

Chronic kidney disease
Death
Drug clearance decreased
Drug toxicity
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

50-59:

Confusion
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Drug hypersensitivity
Hallucination (an experience involving the perception of something not present)
Lymphadenopathy (disease or enlargement of lymph nodes)
Mucocutaneous ulceration (breaks in mucous membranes that are often accompanied by loss of tissue on the surface of mouth)
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)

60+:

Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Actinic keratosis (skin disease due to sun exposure)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Disability
Dyspnoea (difficult or laboured respiration)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Exercise tolerance decreased
Hemiparesis (weakness on one side of the body)
Herpes virus infection
Injury

What are the existing conditions these people have? *

Depression: 4 people, 11.11%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 8.33%
Renal Disorder (kidney disease): 3 people, 8.33%
Oedema (fluid collection in tissue): 3 people, 8.33%
Malaria (a parasitic disease due to mosquito bite): 3 people, 8.33%
Infection: 3 people, 8.33%
High Blood Pressure: 3 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.33%
Pneumonia: 2 people, 5.56%
Lower Respiratory Tract Infection: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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