Phyllocontin and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phyllocontin (aminophylline) and Metformin (metformin hydrochloride). Common drug interactions include anaphylactoid reaction among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Phyllocontin and Metformin. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Phyllocontin?

Phyllocontin has active ingredients of aminophylline. eHealthMe is studying from 547 Phyllocontin users. Check the latest studies of Phyllocontin.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 15, 2026

19 people who take Phyllocontin and Metformin together, and have interactions are studied.

Phyllocontin and Metformin drug interactions.

What are the common drug interactions of Phyllocontin and Metformin, by gender? *:

female:

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Asthma
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Dizziness
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hypertension (high blood pressure)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Pain

male:

Gait disturbance
Headache (pain in head)
Lethargy (tiredness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Pain
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Drug ineffective
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Retinal artery thrombosis (blood clot in retinal artery)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

What are the common drug interactions of Phyllocontin and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Hypertension (high blood pressure)
Asthma
Cough
Dizziness
Dyspnoea (difficult or laboured respiration)
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)

40-49:

Aggression
Asthma
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Erythema (redness of the skin)
Fluid retention (an abnormal accumulation of fluid in the blood)
Lip blister
Local swelling (swelling at the site of some application of substance or injury)
Oral candidiasis (fungal infection of mouth)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Pruritus (severe itching of the skin)

50-59:

Headache (pain in head)
Dizziness
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Panic attack
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)

60+:

Gait disturbance
Pain
Headache (pain in head)
Lethargy (tiredness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Retinal artery thrombosis (blood clot in retinal artery)
Therapeutic response unexpected

What are the existing conditions these people have? *

Cellulitis (infection under the skin): 3 people, 15.79%
Pain: 2 people, 10.53%
Asthma: 2 people, 10.53%
Quit Smoking: 1 person, 5.26%
Epidural Lipomatosis (excessive accumulation of fat within the epidural space -brain): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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