Pioglitazone hydrochloride and Prednisolone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pioglitazone hydrochloride (pioglitazone hydrochloride) and Prednisolone (prednisolone). Common drug interactions include emphysematous cystitis among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Pioglitazone hydrochloride and Prednisolone. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Pioglitazone hydrochloride?

Pioglitazone hydrochloride has active ingredients of pioglitazone hydrochloride. eHealthMe is studying from 2,161 Pioglitazone hydrochloride users. Check the latest studies of Pioglitazone hydrochloride.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

On Jul, 18, 2026

51 people who take Pioglitazone hydrochloride and Prednisolone together, and have interactions are studied.

Pioglitazone hydrochloride and Prednisolone drug interactions.

What are the common drug interactions of Pioglitazone Hydrochloride and Prednisolone, by gender? *:

female:

Emphysematous cystitis (inflammation of the urinary bladder)
Myelosuppression (a decrease in the production of blood cells)
Proteinuria (presence of protein in the urine)
Septic shock (shock due to blood infection)
Venous thrombosis (blood clot (thrombus) that forms within a vein)
Back pain
Chest discomfort
Cholecystitis (infection of gallbladder)
Cough
Diarrhoea haemorrhagic (bloody diarrhoea)

male:

Pyrexia (fever)
Constipation
Cardiomyopathy (weakening of the heart muscle)
Addison's disease (addison's disease, a hormonal disorder disease)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Back pain
C-reactive protein increased
Neutropenia (an abnormally low number of neutrophils)
Still's disease adult onset (a rare illness that causes high fevers, rash, and joint pain in adult just started)
Anaemia (lack of blood)

What are the common drug interactions of Pioglitazone Hydrochloride and Prednisolone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Rebound effect (take-back effect)
Scedosporium infection (a filamentous fungus which occasionally causes infections in humans)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

30-39:

Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Candida sepsis (candida in blood stream)
Cytomegalovirus test positive
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Gamma-glutamyltransferase increased
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypokalaemia (low potassium)

40-49:

n/a

50-59:

Pyrexia (fever)
Aspartate aminotransferase increased
Alanine aminotransferase increased
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Arteriosclerosis (thickening and hardening of arteries)
Candida sepsis (candida in blood stream)
Coronary artery stenosis (narrowing of coronary artery)
Cytomegalovirus test positive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

60+:

Pyrexia (fever)
Hypotension (abnormally low blood pressure)
Cardiomyopathy (weakening of the heart muscle)
Addison's disease (addison's disease, a hormonal disorder disease)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
C-reactive protein increased
Osteonecrosis of jaw (death of bone of jaw)
Still's disease adult onset (a rare illness that causes high fevers, rash, and joint pain in adult just started)
Cardiac failure
Limb injury

What are the existing conditions these people have? *

Diabetes: 19 people, 37.25%
High Blood Pressure: 16 people, 31.37%
Constipation: 10 people, 19.61%
Hypotension (abnormally low blood pressure): 8 people, 15.69%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 8 people, 15.69%
Blood Potassium Decreased: 8 people, 15.69%
Cellulitis (infection under the skin): 8 people, 15.69%
Dehydration (dryness resulting from the removal of water): 8 people, 15.69%
Fever: 8 people, 15.69%
High Blood Cholesterol: 8 people, 15.69%

* Approximation only. Some reports may have incomplete information.

Do you take Pioglitazone hydrochloride and Prednisolone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously