Potassium citrate and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Potassium citrate (potassium citrate) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include migraine among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Potassium citrate and Flexeril. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Potassium citrate?

Potassium citrate has active ingredients of potassium citrate. It is often used in kidney stones. eHealthMe is studying from 5,909 Potassium citrate users. Check the latest studies of Potassium citrate.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

57 people who take Potassium citrate and Flexeril together, and have interactions are studied.

Potassium citrate and Flexeril drug interactions.

What are the common drug interactions of Potassium Citrate and Flexeril, by gender? *:

female:

Migraine (headache)
Pain
Anaemia (lack of blood)
Asthma
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Hepatic neoplasm (liver tumour)
Influenza
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrogenic anaemia (anaemia due to kidney disease)

male:

Chronic kidney disease
Constipation
Anxiety
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Biliary cyst
Bipolar disorder (mood disorder)
Bladder discomfort
Bladder hypertrophy (bladder overgrowth- increase in cell size)
Bladder irritation

What are the common drug interactions of Potassium Citrate and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure increased
Chronic kidney disease
Decreased appetite
Discomfort
Fatigue (feeling of tiredness)
Hypersensitivity
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)

40-49:

Dyspnoea (difficult or laboured respiration)
Adverse event
Nephrogenic anaemia (anaemia due to kidney disease)
Pain
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Drug ineffective
Abdominal pain
Adrenal neoplasm (abnormal growth of adrenal gland)
Anaemia (lack of blood)

50-59:

Renal failure (kidney dysfunction)
Chronic kidney disease
Gastroenteritis (inflammation of stomach and intestine)
Hepatic enzyme increased
Hydronephrosis (water inside the kidney)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Bone neoplasm (tumour of bone)
Cardiac failure congestive
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

60+:

Anaemia (lack of blood)
Intervertebral disc compression (spinal disc compression)
Abdominal pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chronic kidney disease
Coccydynia (pain in the coccyx or tailbone area)
Contusion (a type of hematoma of tissue in which capillaries)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dehydration (dryness resulting from the removal of water)
Drug administration error

What are the existing conditions these people have? *

Pain: 14 people, 24.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 22.81%
Migraine (headache): 10 people, 17.54%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 15.79%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 12.28%
High Blood Pressure: 5 people, 8.77%
High Blood Cholesterol: 5 people, 8.77%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 8.77%
Asthma: 4 people, 7.02%
Multiple Allergies (allergy to multiple agents): 4 people, 7.02%

* Approximation only. Some reports may have incomplete information.

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