Prednisolone and Macrodantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prednisolone (prednisolone) and Macrodantin (nitrofurantoin, macrocrystalline). Common drug interactions include pulmonary congestion among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Prednisolone and Macrodantin. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

On Jul, 19, 2026

25 people who take Prednisolone and Macrodantin together, and have interactions are studied.

Prednisolone and Macrodantin drug interactions.

What are the common drug interactions of Prednisolone and Macrodantin, by gender? *:

female:

Pulmonary congestion (congestion in the lungs)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Rigors (an episode of shaking or exaggerated shivering)
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Taste disturbance
Tremor (trembling or shaking movements in one or more parts of your body)
Ulcer
Vision blurred
Visual acuity reduced (reduced clearness of vision)

male:

Acute respiratory failure
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Hypotension (abnormally low blood pressure)
Lactic acidosis (low ph in body tissues)
Nephrolithiasis (calculi in the kidneys)
Pulse absent
Sepsis syndrome (a clinical condition of blood infection)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Prednisolone and Macrodantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acute respiratory failure
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Pyrexia (fever)
Respiratory tract infection
Biliary tract disorder
Gastritis (inflammation of stomach)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Viral infection
Cardiac arrest

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Immunosuppression

50-59:

Culture urine positive
Dehydration (dryness resulting from the removal of water)
Dry eye (lack of adequate tears)
Escherichia infection (bacterial infection by escherichia coli)
Eye injury
Foot fracture
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Ill-defined disorder

60+:

Abdominal pain
Pain
Blindness unilateral
Blood glucose decreased
Blood in stool
Blood osmolarity decreased
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac failure congestive
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Conjunctivitis (pink eye)

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 4 people, 16.00%
Diabetes: 4 people, 16.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.00%
Oral Herpes (viral infection of mouth): 2 people, 8.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.00%
Hypersensitivity: 2 people, 8.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.00%
Depression: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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