Prednisolone and Sudafed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prednisolone (prednisolone) and Sudafed (pseudoephedrine hydrochloride). Common drug interactions include pruritus among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Prednisolone and Sudafed. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

36 people who take Prednisolone and Sudafed together, and have interactions are studied.

Prednisolone and Sudafed drug interactions.

What are the common drug interactions of Prednisolone and Sudafed, by gender? *:

female:

Pruritus (severe itching of the skin)
Nausea (feeling of having an urge to vomit)
Alanine aminotransferase increased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aspartate aminotransferase increased
Blood bilirubin increased
Chills (felling of cold)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Fatigue (feeling of tiredness)
Gallbladder oedema (swelling of gallbladder)

male:

Dyspnoea (difficult or laboured respiration)
Heart rate increased
Nasopharyngitis (inflammation of the nasopharynx)
Oxygen saturation decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Peripheral swelling
Rash
Renal failure (kidney dysfunction)
Secretion discharge
Viral infection

What are the common drug interactions of Prednisolone and Sudafed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Diarrhoea
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Alanine aminotransferase increased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aspartate aminotransferase increased
Blood bilirubin increased
Chills (felling of cold)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Fatigue (feeling of tiredness)
Gallbladder oedema (swelling of gallbladder)
Hepatitis (inflammation of the liver)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

40-49:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Dry eye (lack of adequate tears)
Pruritus (severe itching of the skin)
Rash pruritic (redness with itching)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dyspnoea (difficult or laboured respiration)
Nasopharyngitis (inflammation of the nasopharynx)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rash

50-59:

Chronic kidney disease
Cryptogenic organizing pneumonia (small airways (bronchioles) and air exchange sac (alveoli) become inflamed with connective tissue)
Dyspnoea (difficult or laboured respiration)
Eye pain
Hordeolum (small collection of pus (abscess) on the eyelid)
Hospitalisation
Malaise (a feeling of general discomfort or uneasiness)
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Surgery

60+:

Pneumonia
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dysphagia (a condition in which swallowing is difficult or painful)
Eye disorder
Haemorrhage (bleeding)
Heart rate increased
Influenza
Influenza like illness
Joint swelling
Laryngeal oedema (swelling of larynx)

What are the existing conditions these people have? *

Sinusitis (inflammation of sinus): 6 people, 16.67%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 5 people, 13.89%
Asthma: 3 people, 8.33%
Depression: 3 people, 8.33%
High Blood Pressure: 3 people, 8.33%
Uveitis (inflammation of the uvea): 2 people, 5.56%
Itching: 2 people, 5.56%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 5.56%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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