Prempro and Lupron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate) and Lupron (leuprolide acetate). Common drug interactions include bone pain among females.

The phase IV clinical study analyzes what interactions people have when they take Prempro and Lupron. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

40 people who take Prempro and Lupron together, and have interactions are studied.

What are the common drug interactions of Prempro and Lupron, by gender? *:

female:

Bone pain
Oedema peripheral (superficial swelling)
Loss of libido (loss of sexual urge)
Optic neuritis (optic nerve inflammation)
Vitamin d decreased
Vulvovaginal dryness
Headache (pain in head)
Abdominal pain
Arthralgia (joint pain)
Myalgia (muscle pain)

male:

n/a

What are the common drug interactions of Prempro and Lupron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Bone pain
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Injection site pain
Myalgia (muscle pain)
Oedema peripheral (superficial swelling)

20-29:

Insomnia (sleeplessness)
Jaw disorder (jaw disease)
Pallor
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulmonary embolism (blockage of the main artery of the lung)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tooth decalcification (a process in which teeth lose calcium)
Tooth disorder (tooth disease)
Tooth extraction
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Bone pain
Migraine (headache)
Oedema peripheral (superficial swelling)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blindness unilateral
Hyperhidrosis (abnormally increased sweating)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Loss of libido (loss of sexual urge)
Malaise (a feeling of general discomfort or uneasiness)
Optic neuritis (optic nerve inflammation)

40-49:

Back pain
Depression
Insomnia (sleeplessness)
Abdominal pain
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Back injury
Bipolar disorder (mood disorder)
Blood cholesterol increased

50-59:

Headache (pain in head)
Abdominal pain upper
Oedema peripheral (superficial swelling)
Rhinorrhoea (watery mucus discharge from the nose)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Brain stem infarction (brainstem stroke)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Hypertension (high blood pressure)
Influenza like illness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

n/a

What are the existing conditions these people have? *

Pelvic Pain: 6 people, 15.00%
Ovarian Cysts (fluid filled sacs of the ovary): 5 people, 12.50%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 3 people, 7.50%
Pain: 2 people, 5.00%
Hot Flush (sudden feelings of heat): 2 people, 5.00%
Depression: 2 people, 5.00%
Birth Control: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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