Primidone and Dexamethasone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primidone (primidone) and Dexamethasone (dexamethasone). Common drug interactions include subcutaneous emphysema among females and tachycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Primidone and Dexamethasone. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

What is Dexamethasone?

Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 161,927 Dexamethasone users. Check the latest studies of Dexamethasone.

On Jul, 26, 2026

78 people who take Primidone and Dexamethasone together, and have interactions are studied.

Primidone and Dexamethasone drug interactions.

What are the common drug interactions of Primidone and Dexamethasone, by gender? *:

female:

Subcutaneous emphysema (smooth bulging of the skin)
Tooth infection
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Venous angioma of brain (benign tumour in the brain)
Hypovolaemia (a decreased volume of circulating blood in the body)
Actinic keratosis (skin disease due to sun exposure)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Seborrhoeic keratosis (noncancerous (benign) skin growths that some people develop as they age. they often appear on the back or chest)

male:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Rash
Oropharyngeal pain
Pruritus (severe itching of the skin)
Syncope (loss of consciousness with an inability to maintain postural tone)
Throat irritation
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Abdominal wall haematoma (abdominal wall blood clotting)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)

What are the common drug interactions of Primidone and Dexamethasone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal wall haematoma (abdominal wall blood clotting)
Bone marrow reticulin fibrosis (thickening and scarring of bone marrow reticulin)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Faecaloma (hard mass of fecal matter)
Fall
Helicobacter gastritis (inflammation of the inner lining of the stomach caused by helicobacter pylori (h. pylori) a bacterium)
Intestinal prolapse
Laceration (tearing of soft body tissue)
Mucous membrane disorder (disease of mucous membrane)
Overdose

20-29:

n/a

30-39:

Apnoea (suspension of external breathing)
Blood bilirubin increased
Blood creatinine increased
Blood pressure increased
Blood uric acid increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disease progression
General physical health deterioration (weak health status)
Papilloedema (optic disc swelling)
Platelet count decreased

40-49:

Back pain
Nerve root compression
Osteoporosis (bones weak and more likely to break)
Spinal compression fracture (fracture due to spinal compression on bone)
Spinal fracture (fracture in one of vertebrae)
Amyloidosis (a tumour within which amyloid is produced)
Ankle fracture
Blood potassium decreased
Blood pressure increased
Cardiac arrest

50-59:

Emotional distress
Fall
Femur fracture
Fluid retention (an abnormal accumulation of fluid in the blood)
Hemiparesis (weakness on one side of the body)
Injection site haematoma (localized swelling filled with blood at injection site)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Migraine (headache)
Overdose

60+:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Rash
Vomiting
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Abdominal pain
Actinic keratosis (skin disease due to sun exposure)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthropathy

What are the existing conditions these people have? *

Blood Pressure Abnormal: 6 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.41%
Pain: 5 people, 6.41%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 6.41%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 5 people, 6.41%
Diabetes: 5 people, 6.41%
Depression: 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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