Prinivil and Lorcet-hd drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinivil (lisinopril) and Lorcet-hd (acetaminophen; hydrocodone bitartrate). Common drug interactions include arthralgia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Prinivil and Lorcet-hd. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Prinivil?

Prinivil has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 20,152 Prinivil users. Check the latest studies of Prinivil.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

On Jul, 15, 2026

28 people who take Prinivil and Lorcet-hd together, and have interactions are studied.

Prinivil and Lorcet-hd drug interactions.

What are the common drug interactions of Prinivil and Lorcet-Hd, by gender? *:

female:

Arthralgia (joint pain)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Respiratory failure (inadequate gas exchange by the respiratory system)
Swelling
Abdominal discomfort

male:

Anxiety
Pain in extremity
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Phlebitis (inflammation of the walls of a vein)
Thrombosis (formation of a blood clot inside a blood vessel)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Back disorder
Blood triglycerides increased

What are the common drug interactions of Prinivil and Lorcet-Hd, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Insomnia (sleeplessness)
Memory impairment
Muscle spasms (muscle contraction)
Pain in extremity
Phlebitis (inflammation of the walls of a vein)
Facial palsy (paralysis of face nerve)
Menstrual disorder (disease of menstrual cycle)

40-49:

Chest pain
Headache (pain in head)
Abdominal distension
Abdominal pain
Anxiety
Back disorder
Cold sweat
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cough

50-59:

Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cellulitis (infection under the skin)
Cervicobrachial syndrome (pain in neck and arm with changing location)
Cholecystitis (infection of gallbladder)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Device related infection
Diabetes mellitus inadequate control

60+:

Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Pleural effusion (water on the lungs)
Pneumonia
Renal failure chronic (long lasting kidney dysfunction)
Type 2 diabetes mellitus
Cardiogenic shock (inadequate circulation of blood)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 21.43%
High Blood Cholesterol: 5 people, 17.86%
Staphylococcal Infection (an infection with staphylococcus bacteria): 3 people, 10.71%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 10.71%
Diabetes: 3 people, 10.71%
Stress And Anxiety: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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