Prinzide and Clopra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinzide (hydrochlorothiazide; lisinopril) and Clopra (metoclopramide hydrochloride). Common drug interactions include eye irritation among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Prinzide and Clopra. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

On Jul, 26, 2026

16 people who take Prinzide and Clopra together, and have interactions are studied.

What are the common drug interactions of Prinzide and Clopra, by gender? *:

female:

Eye irritation
Feeling jittery
Fungal infection
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Laceration (tearing of soft body tissue)
Markedly increased food intake
Non-accidental injury
Septicaemia staphylococcal (blood infection with bacteria)
Staphylococcal infection (an infection with staphylococcus bacteria)
Syncope (loss of consciousness with an inability to maintain postural tone)

male:

Abdominal pain
Arthralgia (joint pain)
Essential hypertension (primary hypertension)
Fatigue (feeling of tiredness)
Gastric ulcer (stomach ulcer)
Heart valve incompetence (heart's valves do not work correctly)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Hypotension (abnormally low blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the common drug interactions of Prinzide and Clopra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Vascular occlusion (sudden blockage of a blood vessel, usually with a clot)
Back pain
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiac disorder
Cyst (a closed sac)
Hypoaesthesia (reduced sense of touch or sensation)
Intervertebral disc protrusion (spinal disc protrusion)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Asthenia (weakness)
Blood creatinine increased

60+:

Arthralgia (joint pain)
Blood glucose increased
Pneumonia
Weight decreased
Intestinal obstruction
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Methicillin-resistant staphylococcal aureus infection
Renal failure acute (rapid kidney dysfunction)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vomiting

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 2 people, 12.50%
Impaired Gastric Emptying: 2 people, 12.50%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 12.50%
Type 2 Diabetes: 1 person, 6.25%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 6.25%
Nerve Injury: 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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