Pristiq and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pristiq (desvenlafaxine succinate) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include constipation among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Pristiq and Hydramine. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. eHealthMe is studying from 19,555 Pristiq users. Check the latest studies of Pristiq.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Aug, 03, 2026

11 people who take Pristiq and Hydramine together, and have interactions are studied.

Pristiq and Hydramine drug interactions.

What are the common drug interactions of Pristiq and Hydramine, by gender? *:

female:

Constipation
Anger
Back pain
Compression fracture (fracture due to pressure caused by injury)
Diarrhoea
Diplopia (double vision)
Dizziness
Drug ineffective
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)

male:

Blood pressure increased
Cardiac disorder
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Erection increased
Pulmonary mycosis (lung infection caused by yeast-like fungi)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Pristiq and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood pressure increased
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)

50-59:

Diplopia (double vision)
Dizziness
Drug ineffective
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)
Feeling hot
Gait disturbance
Hypersomnia (excessive daytime sleepiness (eds))
Infected skin ulcer
Intervertebral disc disorder (spinal disc disorder)

60+:

Pneumonia
Constipation
Pulmonary embolism (blockage of the main artery of the lung)
Application site rash

What are the existing conditions these people have? *

Pain: 5 people, 45.45%
High Blood Pressure: 4 people, 36.36%
Hypersensitivity: 4 people, 36.36%
Urine Abnormality: 3 people, 27.27%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 27.27%
Bipolar Disorder (mood disorder): 3 people, 27.27%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 27.27%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 3 people, 27.27%
Inflammation: 3 people, 27.27%
Migraine (headache): 3 people, 27.27%

* Approximation only. Some reports may have incomplete information.

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