Probenecid and Amoxicillin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Probenecid (probenecid) and Amoxicillin (amoxicillin). Common drug interactions include maternal exposure during pregnancy among females and herpes zoster among males.

The phase IV clinical study analyzes what interactions people have when they take Probenecid and Amoxicillin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Probenecid?

Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

On Jul, 17, 2026

26 people who take Probenecid and Amoxicillin together, and have interactions are studied.

Probenecid and Amoxicillin drug interactions.

What are the common drug interactions of Probenecid and Amoxicillin, by gender? *:

female:

Maternal exposure during pregnancy (use of substance during pregnancy)
Mitral valve hypoplasia (mitral valves are either too small to allow sufficient blood)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Right ventricular hypertrophy (right ventricular enlargement)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Swelling face
Tricuspid valve incompetence (inefficient heart valve)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

male:

Herpes zoster
Pneumonia
Obesity (having too much body fat)
Occipital neuralgia (a condition characterized by chronic pain in the upper neck)
Seborrhoeic dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp)
Tenosynovitis (inflammation of the fluid-filled sheath (called the synovium) that surrounds a tendon)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Cardiac failure congestive
Diarrhoea
Mycosis fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin)

What are the common drug interactions of Probenecid and Amoxicillin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Adenovirus infection
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Cardiac arrest
Epistaxis (bleed from the nose)
Hypertension (high blood pressure)
Lip haemorrhage (bleeding lip)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Stomatitis (inflammation of mucous membrane of mouth)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Asthma
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood alkaline phosphatase increased
Blood triglycerides increased
Dyslipidaemia (abnormal amount of lipids)
Dyspnoea (difficult or laboured respiration)
Herpes zoster
Insomnia (sleeplessness)
Intervertebral disc protrusion (spinal disc protrusion)
Obesity (having too much body fat)

50-59:

Pulmonary embolism (blockage of the main artery of the lung)
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased)
Anaemia (lack of blood)
Bicuspid aortic valve
Cardiac disorder
Cerebral infarction (less blood supply to brain resulting tissue damage)
Coarctation of the aorta (narrowing of the part of aorta)
Colon cancer
Maternal exposure during pregnancy (use of substance during pregnancy)
Mitral valve hypoplasia (mitral valves are either too small to allow sufficient blood)

60+:

Pneumonia
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Pyrexia (fever)
Affective disorder (mental disorder)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aphasia (damage to the parts of the brain that control language)
Asbestosis (chronic lung disease caused by scarring of lung tissue, which stems from prolonged exposure to asbestos)
Asthenia (weakness)
Back pain

What are the existing conditions these people have? *

Insomnia (sleeplessness): 11 people, 42.31%
Hiv Infection: 11 people, 42.31%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 5 people, 19.23%
Depression: 4 people, 15.38%
High Blood Pressure: 4 people, 15.38%
Weight Loss: 4 people, 15.38%
Pain: 4 people, 15.38%
Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 3 people, 11.54%
Lung Disorder (lung disease): 3 people, 11.54%
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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