Probiotic and Wakix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Probiotic (bacillus coagulans) and Wakix (pitolisant hydrochloride). Common drug interactions include fatigue among females and poor quality sleep among males.

The phase IV clinical study analyzes what interactions people have when they take Probiotic and Wakix. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Probiotic?

Probiotic has active ingredients of bacillus coagulans. It is often used in irritable bowel syndrome. eHealthMe is studying from 22,461 Probiotic users. Check the latest studies of Probiotic.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

On Jul, 28, 2026

25 people who take Probiotic and Wakix together, and have interactions are studied.

What are the common drug interactions of Probiotic and Wakix, by gender? *:

female:

Fatigue (feeling of tiredness)
Anxiety
Depression
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Dry eye (lack of adequate tears)
Dry throat
Heart rate increased

male:

Poor quality sleep
Somnolence (a state of near-sleep, a strong desire for sleep)
Inflammation
Lethargy (tiredness)
Limb injury
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Sleep attacks
Therapeutic response unexpected
Wheezing (a high-pitched whistling sound made while you breath)

What are the common drug interactions of Probiotic and Wakix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Anxiety
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Decreased appetite
Depression
Dizziness
Drug intolerance (drug sensitivity)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)

20-29:

n/a

30-39:

Insomnia (sleeplessness)
Depression
Dry eye (lack of adequate tears)
Dry throat
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasal dryness (dry nose)
Nasopharyngitis (inflammation of the nasopharynx)
Pain

40-49:

Anxiety
Fatigue (feeling of tiredness)
Heart rate increased
Blood pressure increased
Headache (pain in head)
Ventricular extrasystoles (premature cardiac contraction)
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Colitis ulcerative (inflammation of colon with ulcer)

50-59:

Back pain
Chest pain
Drug ineffective
Fluid retention (an abnormal accumulation of fluid in the blood)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Peripheral swelling
Weight increased

60+:

Poor quality sleep
Somnolence (a state of near-sleep, a strong desire for sleep)
Fall
Fluid retention (an abnormal accumulation of fluid in the blood)
Fractured coccyx (fracture tail bone)
Headache (pain in head)
Knee arthroplasty
Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
Rash
Rib fracture

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 92.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 60.00%
Drowsiness: 14 people, 56.00%
Heart Rate Increased: 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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