Procardia and Hctz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Procardia (nifedipine) and Hctz (hydrochlorothiazide). Common drug interactions include lacrimation increased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Procardia and Hctz. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Procardia?

Procardia has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 15,151 Procardia users. Check the latest studies of Procardia.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

On Jul, 21, 2026

53 people who take Procardia and Hctz together, and have interactions are studied.

What are the common drug interactions of Procardia and Hctz, by gender? *:

female:

Lacrimation increased
Lethargy (tiredness)
Lymphoedema (localized fluid retention and tissue swelling)
Memory impairment
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Neuropathy peripheral (surface nerve damage)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)

male:

Chronic kidney disease
Back disorder
Pain in extremity
Renal failure (kidney dysfunction)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Burning sensation
Cough
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dyspepsia (indigestion)
Eye disorder

What are the common drug interactions of Procardia and Hctz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Joint effusion (presence of extra fluid in joint covering)
Nausea (feeling of having an urge to vomit)
Pain
Peripheral vascular disorder
Vomiting
Pruritus (severe itching of the skin)
Bipolar disorder (mood disorder)
Erythema (redness of the skin)
Fibromyalgia (a long-term condition which causes pain all over the body)
Fungal infection

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Back pain
Gait disturbance
Oedema peripheral (superficial swelling)
Pain in extremity
Renal failure (kidney dysfunction)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state

50-59:

Pericardial effusion (fluid around the heart)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Multiple injuries
Pain
Arteriovenous fistula
Chills (felling of cold)
Hyperhidrosis (abnormally increased sweating)

60+:

Back disorder
Chronic kidney disease
Alopecia (absence of hair from areas of the body)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic valve incompetence
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Bronchial secretion retention

What are the existing conditions these people have? *

Pain: 12 people, 22.64%
Depression: 7 people, 13.21%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 11.32%
High Blood Cholesterol: 6 people, 11.32%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 9.43%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 9.43%
Diabetes: 5 people, 9.43%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 9.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 7.55%
Multiple Myeloma (cancer of the plasma cells): 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

Do you take Procardia and Hctz?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously