Profen and Choline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Choline (choline). Common drug interactions include unresponsive to stimuli among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Choline. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

What is Choline?

Choline has active ingredients of choline. eHealthMe is studying from 1,037 Choline users. Check the latest studies of Choline.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

49 people who take Profen and Choline together, and have interactions are studied.

What are the common drug interactions of Profen and Choline, by gender? *:

female:

Unresponsive to stimuli
Aggression
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Abdominal discomfort
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dizziness

male:

Gait disturbance
Pyrexia (fever)
Urinary tract infection
Dysphagia (a condition in which swallowing is difficult or painful)
Hepatitis (inflammation of the liver)
Injection site bruising
Injection site discolouration
Injection site pain
Rash generalised (rash on most of body parts)
Scar

What are the common drug interactions of Profen and Choline, by age (0-1 to 60+)? *:

0-1:

Acute hepatic failure
Analgesic drug level increased
Coagulopathy (blood's ability to clot is impaired)
Cough
Depressed level of consciousness
Diarrhoea
Hyperammonaemia
Hyperventilation
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotonia (low muscle tone)

2-9:

n/a

10-19:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Gait disturbance
Heart rate increased
Increased upper airway secretion
Lower respiratory tract infection
Pyrexia (fever)
Respiratory rate increased (excess breathing rate/min)
Urinary tract infection
Dysphagia (a condition in which swallowing is difficult or painful)
Pallor

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hostility
Personality change
Self injurious behaviour
Suicidal ideation
Tearfulness (excess tearing)
Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

Abdominal discomfort
Anorgasmia (type of sexual dysfunction in which a person cannot achieve orgasm, even with adequate stimulation)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Decreased appetite
Depression
Disturbance in attention
Dizziness
Drug ineffective
Fatigue (feeling of tiredness)

40-49:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Occupational exposure to toxic agent
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pelvic venous thrombosis (blood clot occurring inside a blood vessel and thromboses (dvts) that form in the deep veins of the legs or in the pelvic veins)
Post-traumatic stress disorder
Pruritus (severe itching of the skin)
Pyrexia (fever)
Restless legs syndrome (a powerful urge to move your legs)
Road traffic accident
Type 2 diabetes mellitus

50-59:

Hepatitis (inflammation of the liver)
Rash generalised (rash on most of body parts)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Herpes sepsis (whole-body inflammation caused by herpes simplex virus (hsv))
Abdominal discomfort
Anxiety
Arthralgia (joint pain)
Diarrhoea
Fear
Gastric ph decreased

60+:

Confusional state
Fall
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Autoimmune hepatitis
Brain injury
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Decreased appetite
Dementia (madness)
Dysphagia (a condition in which swallowing is difficult or painful)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 30.61%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 16.33%
Depression: 7 people, 14.29%
Upper Respiratory Tract Infection: 5 people, 10.20%
Parkinson's Disease: 5 people, 10.20%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 8.16%
Constipation: 4 people, 8.16%
Fever: 4 people, 8.16%
Sleep Disorder: 4 people, 8.16%
Stress And Anxiety: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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