Profen and Fastin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Fastin (phentermine hydrochloride). Common drug interactions include deep vein thrombosis among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Fastin. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Fastin?

Fastin has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 2,168 Fastin users. Check the latest studies of Fastin.

On Jul, 19, 2026

38 people who take Profen and Fastin together, and have interactions are studied.

What are the common drug interactions of Profen and Fastin, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermoid cyst of ovary (non-cancerous tumour in the ovary that typically contains a diversity of tissues including hair, teeth, bone, thyroid, etc)
Diarrhoea
Distress
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Chronic kidney disease
Chest pain
Valvular heart disease (diseases of the heart valves)

male:

Asthenia (weakness)
Asthma
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Panic disorder
Spinal column stenosis (narrowing of spinal column)

What are the common drug interactions of Profen and Fastin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiovascular disorder (heart diseases)
Cholecystitis acute (rapid infection of gallbladder)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspepsia (indigestion)
Emotional distress
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Gastritis (inflammation of stomach)
General physical health deterioration (weak health status)

30-39:

Asthenia (weakness)
Asthma
Blood cholesterol increased
Chest pain
Heart injury
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Adverse event
Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

40-49:

Anxiety
Asthenia (weakness)
Cardiovascular disorder (heart diseases)
Chest pain
Oesophagitis (inflammation of oesophagus)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Skin hypertrophy (skin cells enlarges)
Tenosynovitis (inflammation of the fluid-filled sheath (called the synovium) that surrounds a tendon)

50-59:

Coma (state of unconsciousness lasting more than six hours)
Dry skin
Memory impairment
Palpitations (feelings or sensations that your heart is pounding or racing)
Respiratory depression (respiration has a rate below 12 breaths)
Small intestinal obstruction (blockage in small intestine)
Thyroid adenoma (a non cancer tumour of the thyroid gland)
Thyroid nodule (a growth (lump) in the thyroid gland)
Tremor (trembling or shaking movements in one or more parts of your body)
Renal failure (kidney dysfunction)

60+:

Cardiovascular disorder (heart diseases)
Chronic kidney disease
Diarrhoea
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 26.32%
Stress And Anxiety: 7 people, 18.42%
Nausea (feeling of having an urge to vomit): 7 people, 18.42%
Headache (pain in head): 7 people, 18.42%
Fever: 7 people, 18.42%
Diabetes: 7 people, 18.42%
Nasopharyngitis (inflammation of the nasopharynx): 6 people, 15.79%
Blood Pressure Abnormal: 6 people, 15.79%
The Flu (the flu is caused by an influenza virus): 5 people, 13.16%
Gastric Disorder (disease of stomach): 5 people, 13.16%

* Approximation only. Some reports may have incomplete information.

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