Profen and Kava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Kava (kava). Common drug interactions include infusion site extravasation among females and hepatic encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Kava. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Kava?

Kava has active ingredients of kava. It is often used in stress and anxiety. eHealthMe is studying from 140 Kava users. Check the latest studies of Kava.

On Jul, 08, 2026

15 people who take Profen and Kava together, and have interactions are studied.

What are the common drug interactions of Profen and Kava, by gender? *:

female:

Infusion site extravasation (flow of (blood or lymph) from infusion site)
Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Abdominal pain
Cytomegalovirus infection
Epstein-barr virus infection
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Laryngitis (inflammation of the larynx)
Pneumonia mycoplasmal (mycoplasma pneumonia (mp) is a contagious respiratory infection)
Asthma

male:

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Urinary tract infection
Confusional state
Delirium (wild excitement)
Drug maladministration
Liver disorder (liver diseases)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the common drug interactions of Profen and Kava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Syncope (loss of consciousness with an inability to maintain postural tone)

30-39:

Bacterial infection
Contusion (a type of hematoma of tissue in which capillaries)
Cytomegalovirus infection
Epstein-barr virus infection
Hypersensitivity
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Laryngitis (inflammation of the larynx)

40-49:

Abdominal pain
Emotional distress
General physical health deterioration (weak health status)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nephrolithiasis (calculi in the kidneys)
Pulmonary embolism (blockage of the main artery of the lung)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chest pain

50-59:

Abdominal tenderness
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

60+:

Urinary tract infection
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Liver disorder (liver diseases)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Panic attack
Pruritus (severe itching of the skin)
Tinnitus (a ringing in the ears)
Vulvovaginal pruritus (vulvovaginal severe itching)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 26.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 20.00%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 1 person, 6.67%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 1 person, 6.67%
Nausea (feeling of having an urge to vomit): 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 6.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 6.67%
Birth Control: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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