Profen and Renagel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Renagel (sevelamer hydrochloride). Common drug interactions include pain in extremity among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Renagel. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Renagel?

Renagel has active ingredients of sevelamer hydrochloride. eHealthMe is studying from 8,246 Renagel users. Check the latest studies of Renagel.

On Jul, 15, 2026

80 people who take Profen and Renagel together, and have interactions are studied.

What are the common drug interactions of Profen and Renagel, by gender? *:

female:

Pain in extremity
Skin hypertrophy (skin cells enlarges)
Pruritus (severe itching of the skin)
Gait disturbance
Emotional distress
Asthenia (weakness)
Chronic kidney disease
Mobility decreased (ability to move is reduced)
Skin induration (an abnormally hard spot or area on the skin)
Arthralgia (joint pain)

male:

Hypertension (high blood pressure)
Anxiety
Asthma
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus inadequate control
Diabetic nephropathy (diabetic kidney disease)
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Infection

What are the common drug interactions of Profen and Renagel, by age (0-1 to 60+)? *:

0-1:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Infection
Respiratory distress (difficulty in breathing)
Therapeutic response decreased (less preventive response)
Transplant rejection (a transplant material is not worked)
Leukopenia (less number of white blood cells in blood)

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Lethargy (tiredness)
Quality of life decreased
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Arthralgia (joint pain)
Atrophy (wasting away of a part of the body)
Dry skin
Exfoliative rash (scaly red generalized skin rash)
Gait disturbance
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)
Joint stiffness

40-49:

Renal failure (kidney dysfunction)
Chronic kidney disease
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Tooth loss
Bone density decreased
Dyspnoea (difficult or laboured respiration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)

50-59:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Emotional distress
Asthenia (weakness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Muscle tightness
Skin induration (an abnormally hard spot or area on the skin)
Acute respiratory failure
Asthma
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus inadequate control

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nausea (feeling of having an urge to vomit)
Acute respiratory failure
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure fluctuation
Cellulitis (infection under the skin)
Chills (felling of cold)
Constipation

What are the existing conditions these people have? *

High Blood Cholesterol: 13 people, 16.25%
High Blood Pressure: 12 people, 15.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 15.00%
Nuclear Magnetic Resonance Imaging Brain: 10 people, 12.50%
Infection: 10 people, 12.50%
Nuclear Magnetic Resonance Imaging Abdominal: 8 people, 10.00%
Depression: 6 people, 7.50%
Hiv Infection: 6 people, 7.50%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 7.50%
Toothaches (tooth pain): 5 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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