Profen and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include mood swings among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Ziac. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

96 people who take Profen and Ziac together, and have interactions are studied.

What are the common drug interactions of Profen and Ziac, by gender? *:

female:

Mood swings (an extreme or rapid change in mood)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nervousness
Pain in extremity
Road traffic accident
Sleep walking (walking during sleep)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary retention (the inability to completely or partially empty the bladder)
Drug effect decreased

male:

Anaemia (lack of blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Asthenia (weakness)
Disease progression
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Flushing (the warm, red condition of human skin)
Myalgia (muscle pain)
Pancreatitis acute (sudden inflammation of pancreas)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal cell carcinoma stage unspecified (kidney cancer in unknown stage)

What are the common drug interactions of Profen and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Depression
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Therapeutic response unexpected
Abdominal pain
Anxiety
Benign hepatic neoplasm (benign (non-cancerous) tumours of the liver)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cellulitis (infection under the skin)
Concussion (short loss of normal brain function in response to a head injury)
Craniocerebral injury (injury to cranium and brain)

40-49:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Anxiety
Arthralgia (joint pain)
Breast cyst
Dyskinesia (abnormality or impairment of voluntary movement)
Mood swings (an extreme or rapid change in mood)
Oedema peripheral (superficial swelling)
Urinary tract infection

50-59:

Cardiac disorder
Dizziness
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Head discomfort
Headache (pain in head)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Infection

60+:

Nausea (feeling of having an urge to vomit)
Osteonecrosis of jaw (death of bone of jaw)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood in stool
Constipation
Cough
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspepsia (indigestion)
Dysphonia (speech disorder attributable to a disorder of phonation)

What are the existing conditions these people have? *

Depression: 19 people, 19.79%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 17 people, 17.71%
Sleep Disorder: 16 people, 16.67%
Nausea (feeling of having an urge to vomit): 15 people, 15.62%
Muscle Spasms (muscle contraction): 15 people, 15.62%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 13 people, 13.54%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 11.46%
Stress And Anxiety: 6 people, 6.25%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 6.25%
Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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