Prograf and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prograf (tacrolimus) and Zanaflex (tizanidine hydrochloride). Common drug interactions include thrombosis among females and parainfluenzae virus infection among males.

The phase IV clinical study analyzes what interactions people have when they take Prograf and Zanaflex. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On May, 21, 2026

30 people who take Prograf and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Prograf and Zanaflex, by gender? *:

female:

Thrombosis (formation of a blood clot inside a blood vessel)
Surgery
Blood pressure increased
Mania (a state of abnormally elevated or irritable mood)
Chronic kidney disease
Decreased appetite
Depression
Drug hypersensitivity
Gout (uric acid crystals building up in the body)
Irritability

male:

Parainfluenzae virus infection
Headache (pain in head)
Cardiac arrest
Infected skin ulcer
Localised infection (infection at the single location)
Respiratory failure (inadequate gas exchange by the respiratory system)
Transplant failure (transplantation failed to meet outcome)
Urinary tract infection
Atelectasis (partial or complete collapse of the lung)
Blood pressure systolic increased

What are the common drug interactions of Prograf and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood culture positive
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cytomegalovirus infection
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Febrile neutropenia (fever with reduced white blood cells)
General physical health deterioration (weak health status)
Immunodeficiency
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)

40-49:

Chronic kidney disease
Depression
Chronic allograft nephropathy (failure of kidney transplant)
Fatigue (feeling of tiredness)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Proteinuria (presence of protein in the urine)
Pyuria (a condition of urine containing pus)
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Coma (state of unconsciousness lasting more than six hours)

50-59:

Parainfluenzae virus infection
Headache (pain in head)
Chest pain
Cough
Dyspnoea (difficult or laboured respiration)
Respiratory tract infection fungal
Atelectasis (partial or complete collapse of the lung)
Blood pressure systolic increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort

60+:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection
Thrombosis (formation of a blood clot inside a blood vessel)
Candida sepsis (candida in blood stream)
Cardiac arrest
Infected skin ulcer
Localised infection (infection at the single location)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 23.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 16.67%
Drowsiness: 5 people, 16.67%
Pain: 3 people, 10.00%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 6.67%
Neuropathy Peripheral (surface nerve damage): 2 people, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.67%
High Blood Cholesterol: 2 people, 6.67%
Diabetes: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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