Prolia and Sustiva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Sustiva (efavirenz). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Sustiva. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

What is Sustiva?

Sustiva has active ingredients of efavirenz. It is often used in hiv infection. eHealthMe is studying from 11,040 Sustiva users. Check the latest studies of Sustiva.

On Jul, 27, 2026

12 people who take Prolia and Sustiva together, and have interactions are studied.

What are the common drug interactions of Prolia and Sustiva, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Depression
Drug ineffective
Gait disturbance
Asthenia (weakness)
Blood creatinine increased
Chronic kidney disease

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Foot fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Decreased activity
Hand fracture
Acidosis (build-up of carbon dioxide in the blood)
Anaemia (lack of blood)
Arthralgia (joint pain)
Blood creatinine increased

What are the common drug interactions of Prolia and Sustiva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Gait disturbance
Hyperlipidaemia (presence of excess lipids in the blood)
Micturition disorder (disease of passing urine)
Mobility decreased (ability to move is reduced)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Decreased activity
Emotional distress
Hand fracture
Pain

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Gait disturbance
Osteopenia (a condition where bone mineral density is lower than normal)
Emotional distress
Hip fracture
Bone density decreased
Femur fracture
Pain
Arthralgia (joint pain)

What are the existing conditions these people have? *

Hiv Infection: 12 people, 100.00%
Hypersensitivity: 3 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
Pain: 3 people, 25.00%
Herpes Zoster: 3 people, 25.00%
High Blood Pressure: 2 people, 16.67%
Depression: 2 people, 16.67%
Insomnia (sleeplessness): 2 people, 16.67%
Erection Problems: 2 people, 16.67%
Diarrhea: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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