Promethazine with codeine and Diazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine with codeine (codeine phosphate; promethazine hydrochloride) and Diazepam (diazepam). Common drug interactions include chronic kidney disease among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine with codeine and Diazepam. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine with codeine?

Promethazine with codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 269 Promethazine with codeine users. Check the latest studies of Promethazine with codeine.

What is Diazepam?

Diazepam has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 108,384 Diazepam users. Check the latest studies of Diazepam.

On Jul, 25, 2026

14 people who take Promethazine with codeine and Diazepam together, and have interactions are studied.

Promethazine with codeine and Diazepam drug interactions.

What are the common drug interactions of Promethazine With Codeine and Diazepam, by gender? *:

female:

Chronic kidney disease
Drug dependence
Pneumonia
Alanine aminotransferase increased
Anaphylactic reaction (serious allergic reaction)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Asthma
Back pain
Cardiac failure congestive

male:

Depression
Pain
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Arthralgia (joint pain)
Bedridden
Blood testosterone decreased
Body height decreased
Bone disorder
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cartilage atrophy (cartilage extra growth)

What are the common drug interactions of Promethazine With Codeine and Diazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Weight decreased

50-59:

Arthralgia (joint pain)
Drug dependence
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Bedridden
Blood testosterone decreased
Body height decreased
Bone disorder
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cartilage atrophy (cartilage extra growth)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Cataract (clouding of the lens inside the eye)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Dysphagia (a condition in which swallowing is difficult or painful)
Hyperlipidaemia (presence of excess lipids in the blood)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Nephrolithiasis (calculi in the kidneys)
Pneumonia

What are the existing conditions these people have? *

High Blood Cholesterol: 4 people, 28.57%
Pain: 4 people, 28.57%
Indigestion: 4 people, 28.57%
Dyspnea (difficult or laboured breathing): 4 people, 28.57%
High Blood Pressure: 4 people, 28.57%
Hypersensitivity: 3 people, 21.43%
Inflammation: 3 people, 21.43%
Insomnia (sleeplessness): 3 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 21.43%
Gastric Ulcer (stomach ulcer): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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