Promethazine and Amoxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Amoxil (amoxicillin). Common drug interactions include tooth fracture among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Amoxil. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Amoxil?

Amoxil has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 3,641 Amoxil users. Check the latest studies of Amoxil.

On Jul, 09, 2026

40 people who take Promethazine and Amoxil together, and have interactions are studied.

Promethazine and Amoxil drug interactions.

What are the common drug interactions of Promethazine and Amoxil, by gender? *:

female:

Tooth fracture
Toothache (tooth pain)
Abdominal pain
Aspartate aminotransferase increased
Blood bilirubin increased
Blood cholesterol increased
Blood corticotrophin decreased
Bone density decreased
Decreased appetite
Dehydration (dryness resulting from the removal of water)

male:

Asthenia (weakness)
Blood pressure decreased
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve disease mixed
Bicuspid aortic valve
Death
Depression
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Dystonia (abnormal muscle tone)

What are the common drug interactions of Promethazine and Amoxil, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Apgar score low
Birth trauma (damage of the tissues and organs of a newly delivered child)
Gingival cyst (an uncommon cyst of gingival soft tissue occurring in either the free or attached gums)
Hydrocele
Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Otitis media chronic (long lasting inflammation of the middle ear)
Persistent foetal circulation (baby's blood does not need to pass by the lungs)
Shoulder dystocia (after the delivery of the head, the anterior shoulder of the infant cannot pass below the pubic symphysis)
Umbilical cord around neck

2-9:

n/a

10-19:

Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood bilirubin increased
Blood corticotrophin decreased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dizziness
Haematocrit decreased

20-29:

n/a

30-39:

n/a

40-49:

Emotional distress
Episcleritis (acute inflammatory disorder of the episclera of eye)
Erectile dysfunction
Eye pain
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
General physical health deterioration (weak health status)
Gingival abscess (pus in gums)
Gingival bleeding (bleeding gums)
Gingival erythema (redness of gums)

50-59:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve disease mixed
Bicuspid aortic valve
Death
Emotional distress
Endocarditis (inflammation in heart muscle)

60+:

Chronic kidney disease
Anaemia (lack of blood)
Renal tubular necrosis (death of kidney tubules)
Dizziness
Febrile neutropenia (fever with reduced white blood cells)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Septic shock (shock due to blood infection)
Bone marrow failure
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 40.00%
Pain: 16 people, 40.00%
Depression: 13 people, 32.50%
Stress And Anxiety: 12 people, 30.00%
Diabetes: 8 people, 20.00%
High Blood Pressure: 6 people, 15.00%
Asthma: 6 people, 15.00%
Gastric Ulcer (stomach ulcer): 5 people, 12.50%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 12.50%
Muscle Aches (muscle pain): 5 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine and Amoxil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously