Promethazine and Combigan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Combigan (brimonidine tartrate; timolol maleate). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Combigan. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

On Jul, 11, 2026

43 people who take Promethazine and Combigan together, and have interactions are studied.

Promethazine and Combigan drug interactions.

What are the common drug interactions of Promethazine and Combigan, by gender? *:

female:

Chronic kidney disease
Infection
Sinusitis (inflammation of sinus)
Upper respiratory tract infection
Injection site erythema (redness at injection site)
Renal failure (kidney dysfunction)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Urinary tract infection
Herpes zoster
Renal injury (kidney injury)

male:

Chronic kidney disease
Conjunctival erosion (removal of conjunctiva)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Renal injury (kidney injury)
Swollen tongue (swelling of tongue)
Renal failure (kidney dysfunction)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Anaemia of chronic disease
Cellulitis (infection under the skin)
Diarrhoea haemorrhagic (bloody diarrhoea)

What are the common drug interactions of Promethazine and Combigan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea haemorrhagic (bloody diarrhoea)

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Intraocular pressure increased
Visual impairment
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Abscess limb (limb infection)
Adverse drug reaction
Anal abscess
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Dyspnoea (difficult or laboured respiration)
Emotional distress

60+:

Infection
Injection site erythema (redness at injection site)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Contusion (a type of hematoma of tissue in which capillaries)
Anaemia of chronic disease
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Breast cancer
Cardiac failure chronic
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 27.91%
High Blood Pressure: 9 people, 20.93%
Immunodeficiency Common Variable: 8 people, 18.60%
Pain: 6 people, 13.95%
Infection: 6 people, 13.95%
Type 2 Diabetes: 5 people, 11.63%
High Blood Cholesterol: 5 people, 11.63%
Diabetes: 4 people, 9.30%
Eye Disorder: 4 people, 9.30%
Gout (uric acid crystals building up in the body): 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine and Combigan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously