1. Home
  2. Analysis
  3. Promethazine
  4. Licorice

Promethazine and Licorice drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Licorice (licorice). Common drug interactions include platelet count decreased among females.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Licorice. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Licorice?

Licorice has active ingredients of licorice. eHealthMe is studying from 420 Licorice users. Check the latest studies of Licorice.

On Jul, 15, 2026

14 people who take Promethazine and Licorice together, and have interactions are studied.

Promethazine and Licorice drug interactions.

What are the common drug interactions of Promethazine and Licorice, by gender? *:

female:

  1. Platelet count decreased
  2. Myelosuppression (a decrease in the production of blood cells)
  3. Weight increased
  4. Cough
  5. Fall
  6. Fatigue (feeling of tiredness)
  7. Headache (pain in head)
  8. Impaired healing
  9. Influenza like illness
  10. Lethargy (tiredness)

male:

n/a

What are the common drug interactions of Promethazine and Licorice, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Ear discomfort
  2. Insomnia (sleeplessness)
  3. Libido increased (increased sexual urge to have sex)
  4. Sensory disturbance (sense disturbance)
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  6. Therapeutic response unexpected
  7. Weight increased

60+:

  1. Platelet count decreased
  2. Myelosuppression (a decrease in the production of blood cells)
  3. Bone marrow failure

What are the existing conditions these people have? *

  1. Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 8 people, 57.14%
  2. Nausea And Vomiting: 6 people, 42.86%
  3. Rashes (redness): 5 people, 35.71%
  4. Platelet Count Increased: 5 people, 35.71%
  5. Ovarian Cancer Stage Iii: 5 people, 35.71%
  6. Local Anaesthesia: 5 people, 35.71%
  7. Allergies: 5 people, 35.71%
  8. Psychomotor Hyperactivity (feelings of extreme restlessness): 1 person, 7.14%
  9. Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine and Licorice?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Promethazine and Licorice:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Promethazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Licorice:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Promethazine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Licorice and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on promethazine hydrochloride and licorice (the active ingredients of Promethazine and Licorice, respectively), and Promethazine and Licorice (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.