Provigil and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include exostosis among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Hydrocodone. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 09, 2026

87 people who take Provigil and Hydrocodone together, and have interactions are studied.

Provigil and Hydrocodone drug interactions.

What are the common drug interactions of Provigil and Hydrocodone, by gender? *:

female:

Exostosis (formation of new bone on the surface of a bone)
Loss of consciousness
Memory impairment
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Muscle spasms (muscle contraction)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nonspecific reaction (unspecified reaction)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Osteopenia (a condition where bone mineral density is lower than normal)

male:

Depression
Road traffic accident
Substance abuse
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Erectile dysfunction
Hallucination (an experience involving the perception of something not present)
Abnormal behaviour
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cardiac failure congestive
Concussion (short loss of normal brain function in response to a head injury)

What are the common drug interactions of Provigil and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Cholecystitis chronic (long lasting infection of gallbladder)
Emotional disorder
Gallbladder disorder
Injury
Pain
Psychological trauma
Pulmonary embolism (blockage of the main artery of the lung)
Alanine aminotransferase increased
Aspartate aminotransferase increased

30-39:

Anxiety
Pain
Abdominal pain
Apnoea (suspension of external breathing)
Atonic urinary bladder (large urinary bladders that have become dilated but are not emptying properly)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Headache (pain in head)
Multiple drug overdose accidental
Nausea (feeling of having an urge to vomit)

40-49:

Depression
Foot fracture
Road traffic accident
Back disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Neck injury
Pruritus (severe itching of the skin)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Substance abuse
Suicidal ideation

50-59:

Blood potassium decreased
Drug ineffective
Headache (pain in head)
Pain
Thrombosis (formation of a blood clot inside a blood vessel)
Aggression
Atrioventricular block second degree (heart block second degree)
Blood magnesium decreased
Brain natriuretic peptide increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

60+:

Colitis (inflammation of colon)
Erectile dysfunction
Dissociation
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle tightness
Myalgia (muscle pain)
Small intestine carcinoma (cancer tumour of small intestine)
Stomach discomfort (pain in abdomen)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 27.59%
Pain: 17 people, 19.54%
Drowsiness: 12 people, 13.79%
Stress And Anxiety: 10 people, 11.49%
Nausea (feeling of having an urge to vomit): 9 people, 10.34%
Headache (pain in head): 9 people, 10.34%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.20%
Muscle Spasms (muscle contraction): 8 people, 9.20%
Depression: 8 people, 9.20%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 9.20%

* Approximation only. Some reports may have incomplete information.

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