Purinethol and Xanax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Purinethol (mercaptopurine) and Xanax (alprazolam). Common drug interactions include acute respiratory failure among females and cholestasis among males.

The phase IV clinical study analyzes what interactions people have when they take Purinethol and Xanax. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Purinethol?

Purinethol has active ingredients of mercaptopurine. It is often used in ulcerative colitis. eHealthMe is studying from 3,810 Purinethol users. Check the latest studies of Purinethol.

What is Xanax?

Xanax has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 135,347 Xanax users. Check the latest studies of Xanax.

On Jul, 12, 2026

45 people who take Purinethol and Xanax together, and have interactions are studied.

What are the common drug interactions of Purinethol and Xanax, by gender? *:

female:

Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Antinuclear antibody positive
Confusional state
Crying
Depression
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemorrhage intracranial (bleeding within the skull)

male:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Acidosis (build-up of carbon dioxide in the blood)
Acute respiratory distress syndrome
Arrhythmia (irregular heartbeat)
Ascites (accumulation of fluid in the abdominal cavity)
Blood triglycerides increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure
Cardiac failure congestive

What are the common drug interactions of Purinethol and Xanax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatomegaly (abnormal enlargement of the liver)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Aplasia (defective development or congenital absence of an organ or tissue)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Mucosal inflammation (infection of mucous membrane)
Overdose
Renal failure acute (rapid kidney dysfunction)

20-29:

Hepatitis toxic

30-39:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Migraine (headache)
Headache (pain in head)
Pulmonary embolism (blockage of the main artery of the lung)
Cough
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Mobility decreased (ability to move is reduced)

40-49:

Blood triglycerides increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Coagulation factor viii level increased
Colonic stenosis (abnormal narrowing of colon)
Constipation
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dehydration (dryness resulting from the removal of water)

50-59:

Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
Calculus bladder (bladder stone)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)
Polyp
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Angiopathy (generic term for a disease of the blood vessels)
Blood glucose increased

60+:

Dyspnoea (difficult or laboured respiration)
Cardiac failure
Blood pressure increased
Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Cytomegalovirus infection
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer)
Fall
Gastrointestinal oedema (excessive build-up of fluid in the gastrointestinal tract tissues)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 15.56%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 11.11%
Rickets (softening of bones): 4 people, 8.89%
Respiratory Tract Infection: 4 people, 8.89%
Pain: 4 people, 8.89%
Nausea (feeling of having an urge to vomit): 4 people, 8.89%
Insomnia (sleeplessness): 4 people, 8.89%
Hypersensitivity: 4 people, 8.89%
High Blood Pressure: 4 people, 8.89%
Abdominal Distension: 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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