Pyridium and Restasis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridium (phenazopyridine hydrochloride) and Restasis (cyclosporine). Common drug interactions include fall among females.

The phase IV clinical study analyzes what interactions people have when they take Pyridium and Restasis. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

59 people who take Pyridium and Restasis together, and have interactions are studied.

Pyridium and Restasis drug interactions.

What are the common drug interactions of Pyridium and Restasis, by gender? *:

female:

Fall
Renal failure (kidney dysfunction)
Muscular weakness (muscle weakness)
Osteoporosis (bones weak and more likely to break)
Pain
Asthenia (weakness)
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypoaesthesia (reduced sense of touch or sensation)

male:

n/a

What are the common drug interactions of Pyridium and Restasis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Contusion (a type of hematoma of tissue in which capillaries)
Haemorrhagic diathesis (bleeding tendency)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

20-29:

n/a

30-39:

Glaucoma (increased fluid pressure in the eye with vision loss)
Paraneoplastic retinopathy
Retinal disorder (disease of retina)
Injection site pain
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)

40-49:

Injection site mass
Injection site pain
Injection site reaction

50-59:

Cough
Hypokalaemia (low potassium)
Loss of consciousness
Memory impairment
Acute respiratory failure
Asthenia (weakness)
Bladder dysfunction
Bradycardia (abnormally slow heart action)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Colitis ulcerative (inflammation of colon with ulcer)

60+:

Drug ineffective
Asthenia (weakness)
Fall
Hyperhidrosis (abnormally increased sweating)
Impaired gastric emptying
Lymphocyte count decreased
Malaise (a feeling of general discomfort or uneasiness)
Mobility decreased (ability to move is reduced)
Vomiting
Weight decreased

What are the existing conditions these people have? *

Pain: 13 people, 22.03%
Stress And Anxiety: 9 people, 15.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 11.86%
Depression: 7 people, 11.86%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 11.86%
Muscle Spasms (muscle contraction): 6 people, 10.17%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 10.17%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.17%
Fluid Imbalance (imbalance of fluid in body in intake and fluid lost): 5 people, 8.47%
Nausea (feeling of having an urge to vomit): 5 people, 8.47%

* Approximation only. Some reports may have incomplete information.

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