Quinine and Metformin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Quinine (cinchona) and Metformin hydrochloride (metformin hydrochloride). Common drug interactions include coma among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Quinine and Metformin hydrochloride. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Quinine?

Quinine has active ingredients of cinchona. It is often used in leg pain. eHealthMe is studying from 4,981 Quinine users. Check the latest studies of Quinine.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 58,646 Metformin hydrochloride users. Check the latest studies of Metformin hydrochloride.

On Aug, 11, 2026

29 people who take Quinine and Metformin hydrochloride together, and have interactions are studied.

Quinine and Metformin hydrochloride drug interactions.

What are the common drug interactions of Quinine and Metformin Hydrochloride, by gender? *:

female:

Coma (state of unconsciousness lasting more than six hours)
Hypotension (abnormally low blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain
Cellulitis (infection under the skin)
Overdose
Acidosis (build-up of carbon dioxide in the blood)
Acute phosphate nephropathy (sudden damage to the kidneys caused by the formation of phosphate crystals)
Anaemia (lack of blood)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)

male:

Diarrhoea
Muscle spasms (muscle contraction)
Death
Dehydration (dryness resulting from the removal of water)
Drug level above therapeutic
Electrocardiogram pr prolongation
Fatigue (feeling of tiredness)
Gait disturbance
Hyperkalaemia (damage to or disease of the kidney)
Infusion related reaction

What are the common drug interactions of Quinine and Metformin Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Acute phosphate nephropathy (sudden damage to the kidneys caused by the formation of phosphate crystals)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)

30-39:

n/a

40-49:

n/a

50-59:

Coma (state of unconsciousness lasting more than six hours)
Hypotension (abnormally low blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Overdose
Abdominal distension
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Blood pressure systolic increased
Diarrhoea
Infusion related reaction
Muscle spasms (muscle contraction)

60+:

Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)
Death
Dehydration (dryness resulting from the removal of water)
Delirium (wild excitement)
Drug level above therapeutic
Dyspnoea (difficult or laboured respiration)
Electrocardiogram pr prolongation
Fatigue (feeling of tiredness)
Gait disturbance

What are the existing conditions these people have? *

Type 2 Diabetes: 3 people, 10.34%
Muscle Spasms (muscle contraction): 2 people, 6.90%
High Blood Cholesterol: 2 people, 6.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.90%
Constipation: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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