Riluzole and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Riluzole (riluzole) and Acetaminophen (acetaminophen). Common drug interactions include cholestasis among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Riluzole and Acetaminophen. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Riluzole?

Riluzole has active ingredients of riluzole. It is often used in amyotrophic lateral sclerosis. eHealthMe is studying from 1,621 Riluzole users. Check the latest studies of Riluzole.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

35 people who take Riluzole and Acetaminophen together, and have interactions are studied.

Riluzole and Acetaminophen drug interactions.

What are the common drug interactions of Riluzole and Acetaminophen, by gender? *:

female:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Jaundice cholestatic
Nausea (feeling of having an urge to vomit)
Abscess (pus)
Dyspnoea (difficult or laboured respiration)
Abdominal pain upper
Decreased appetite
Diarrhoea
Ileus (a painful obstruction of the ileum or other part of the intestine)
Pancreatitis acute (sudden inflammation of pancreas)

male:

Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Pancreatitis (inflammation of pancreas)
Somnolence (a state of near-sleep, a strong desire for sleep)
Ureteric obstruction
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Abdominal pain
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Blood bilirubin increased

What are the common drug interactions of Riluzole and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Myocarditis (inflammation of heart muscle myocardium)
Ureteric obstruction

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Depression
Abscess (pus)
Dysphagia (a condition in which swallowing is difficult or painful)
Pancreatitis (inflammation of pancreas)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary tract infection
Abdominal pain upper
Decreased appetite

What are the existing conditions these people have? *

Salivary Hypersecretion (excess saliva secretion): 3 people, 8.57%
Dizziness: 3 people, 8.57%
Blood Potassium Decreased: 3 people, 8.57%
Neck Pain: 2 people, 5.71%
Constipation: 2 people, 5.71%
Bipolar Disorder (mood disorder): 2 people, 5.71%
Asthma: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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