Ritalin and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Aldactone (spironolactone). Common drug interactions include blood glucose increased among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Aldactone. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 10, 2026

84 people who take Ritalin and Aldactone together, and have interactions are studied.

Ritalin and Aldactone drug interactions.

What are the common drug interactions of Ritalin and Aldactone, by gender? *:

female:

Blood glucose increased
Fall
Pyrexia (fever)
General physical health deterioration (weak health status)
Migraine (headache)
Pain
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Blood pressure decreased

male:

Fatigue (feeling of tiredness)
Fall
Constipation
Insomnia (sleeplessness)
Hypotension (abnormally low blood pressure)
Anxiety
Asthenia (weakness)
Balance disorder
Contusion (a type of hematoma of tissue in which capillaries)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Ritalin and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

30-39:

Anxiety
Emotional distress
Gallbladder disorder
Injury
Pain
Psychological trauma
Accommodation disorder
Cholecystitis chronic (long lasting infection of gallbladder)
Confusional state
Disease progression

40-49:

Fatigue (feeling of tiredness)
Blood glucose increased
Malaise (a feeling of general discomfort or uneasiness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain
Back pain
Blood triglycerides increased
Contusion (a type of hematoma of tissue in which capillaries)
Dry skin
Fall

50-59:

Abdominal pain
Abdominal pain upper
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Back pain
Bone pain
Brachial plexopathy (pain, decreased movement, or decreased sensation in the arm and shoulder due to a nerve problem)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Chest discomfort
Decreased appetite

60+:

Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Weight decreased
Insomnia (sleeplessness)
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase decreased
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Balance disorder

What are the existing conditions these people have? *

Pain: 15 people, 17.86%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 16.67%
Prostate Cancer: 12 people, 14.29%
Metastases To Bone (cancer spreads to bone): 12 people, 14.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 10.71%
Carcinoid Tumor: 8 people, 9.52%
Oedema (fluid collection in tissue): 6 people, 7.14%
Hypokalemia (low potassium): 6 people, 7.14%
High Blood Pressure: 6 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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